Posted 18 February 2006 - 12:48 AM
For what it's worth, 800mg/day for 8 weeks, in children. Still working on finding long term dosing studies.
One cautionary interpretation of the abstract below would be that at 800mg/day, one is seeing statistically significant neurological effects. A further negative spin might be -- "this means one is moving from the dietarily significant to the pharmacological". While I suspect some in this group are reasonably comfortable with knowing that much of what they ingest as "supplements" are actually well into the range of pharmacologica agents, using the reference below, and combining it with the beef ingestion study (ca. 250 mg >> 5.5 hours coverage) one might be inclined to cut back to a few hundred milligrams per day, in single dose, if one wanted to bias one's intake toward what's more dietarily relevant.
On the other hand, clearly 800mg per day is having some neuropharmacological effect, per the study below.
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J Child Neurol. 2002 Nov;17(11):833-7. Related Articles, Links
Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders.
Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, Komen J.
Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL 60044, USA. mchezmd@interaccess.com
L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with gamma-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects. We investigated 31 children with autistic spectrum disorders in an 8-week, double-blinded study to determine if 800 mg L-carnosine daily would result in observable changes versus placebo. Outcome measures were the Childhood Autism Rating Scale, the Gilliam Autism Rating Scale, the Expressive and Receptive One-Word Picture Vocabulary tests, and Clinical Global Impressions of Change. Children on placebo did not show statistically significant changes. After 8 weeks on L-carnosine, children showed statistically significant improvements on the Gilliam Autism Rating Scale (total score and the Behavior, Socialization, and Communication subscales) and the Receptive One-Word Picture Vocabulary test (all P < .05). Improved trends were noted on other outcome measures. Although the mechanism of action of L-carnosine is not well understood, it may enhance neurologic function, perhaps in the enterorhinal or temporal cortex.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 12585724 [PubMed - indexed for MEDLINE]
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