12 replies to this topic

[long3vity]

How much arketamine can you take intranasally and how often for it to have maximum antidepressant effect and neurogenesis? I've grown tolerance to the substance but it still works, but I have to take slightly higher dosages. I read that arketamine is a 5 times less potent NMDA-antagonist than regular ketamine and 8 times less potent dopamine agonist than s-ketamine, which basically means that r-ketamine lacks psychotomimetic effects. How safe is arketamine then in terms of addiction? 

[Mind_Paralysis]

Probably safer.

 

HOWever... the most recent research does implicate the metabolite 6-HydroxyNorKetamine as the component of Ketamine causing the most long-term antidepressant effects - through AMPA-agonism.

 

I would suggest that instead of using R-ketamine that you try and organise a group buy to manufacture 6-HNK, and then use that instead.

[YoungSchizo]

https://www.drugtarg...oxynorketamine/

 

I might be interested in a group-buy for 6-HydroxyNorKetamine. (off course, if I can afford it.)

[normalizing]

if ketamine works through AMPA there are many other things out there who do that too. also for NMDA, you can make a combo and somehow imitate the effect, no?

[Zibibbo]

Considering that:

 

-2R,6R HNKetamine molecule is more effective than his brother 2S, 6S

- R-Ketamine enantiomer have several time less psychotomimetic effect than RS-Ket
-buying HNK actually is unbelievable expensive

 

I'm thinking it have sense to use R-Ketamine for treat depression and suicidality, actually.
Waiting for more experienced answers.

[normalizing]

where are you going to buy it from??

[long3vity]

Probably safer.

 

HOWever... the most recent research does implicate the metabolite 6-HydroxyNorKetamine as the component of Ketamine causing the most long-term antidepressant effects - through AMPA-agonism.

 

I would suggest that instead of using R-ketamine that you try and organise a group buy to manufacture 6-HNK, and then use that instead.

I'd really love to try and organise a group buy as i'm definitely interested in this compound. I just don't know how I would go about to organise such a thing? I'm quite new here hehe..

[long3vity]

if ketamine works through AMPA there are many other things out there who do that too. also for NMDA, you can make a combo and somehow imitate the effect, no?

Could you give us an example of other ampa agonists? The only ones I found are on wiki and they are just a dozen, most of them being still in research and never tried on humans before so potentially dangerous. Arketamine also affects the alpha-7-nicotinic receptor which could also be responsible for its antidepressant effect

[Mind_Paralysis]

 

if ketamine works through AMPA there are many other things out there who do that too. also for NMDA, you can make a combo and somehow imitate the effect, no?

Could you give us an example of other ampa agonists? The only ones I found are on wiki and they are just a dozen, most of them being still in research and never tried on humans before so potentially dangerous. Arketamine also affects the alpha-7-nicotinic receptor which could also be responsible for its antidepressant effect

 

 

The Alpha-7-nicotinic antagonism it displays is most likely responsible for the anxiolytic effects though, the lessening of anxiety and the calming effects - we've got a whole thread on how the Alpha-7-receptors control the output from the amygdala, and how such effects could be useful in treating BORDERLINE.

 

So, not necessarily responsible for the AD-effects.

 

For another AMPA-agonist, which also works sort-of like a NMDA-antagonist, then look no further than to good old TIANEPTINE. It works a bit more like Lamotrigine in a sense though, as it MODULATES, aka more stabilises, the electrical impulses controlled by both AMPA and NMDA-receptors - it alters the activity between both of them.

 

I'm guessing you've never tried Tianeptine? I don't believe it's available in your jurisdiction, so that's understandable - it's available from several reliable online vendors though.

[normalizing]

yeah but be careful, tianeptine is partly opioid and you will feel it on and off taking it

[Zibibbo]

 

Probably safer.

 

HOWever... the most recent research does implicate the metabolite 6-HydroxyNorKetamine as the component of Ketamine causing the most long-term antidepressant effects - through AMPA-agonism.

 

I would suggest that instead of using R-ketamine that you try and organise a group buy to manufacture 6-HNK, and then use that instead.

I'd really love to try and organise a group buy as i'm definitely interested in this compound. I just don't know how I would go about to organise such a thing? I'm quite new here hehe..

 

ask hnk6@tunanota.com

It could take weeks for a reply but i can confirm they are active and read the mail.

Ask them and let us know if there are any news.

 

Ah, you have PM!

Edited by Zibibbo, 17 August 2017 - 01:42 PM.

[samson75]

@long3vity :

hello, you say that "it stills work". Can you tell more about your experience with this ?

The level of your depression and the detail of the benefits you got from it ?

I read a lot about groupbuys and posts like yours but never a good review of the

outcomes on the illness.

 

Thank you.

[peoplepleaser101]

I'm interested in the metabolite as well. Count me in