Interesting post on reddit
"If you don't mind me asking, there is something else which might be associated with low MAO-A, I believe. Those of us with low MAO-A probably get higher peak dopamine levels. This may lead to desensitization/downregulation of dopamine receptors. This in turn could lead to some anhedonia or apathy."
If you have low MAO-A, the NT turnover is slower so yes we probably get higher peak levels and lots of downregulation and less is available to the brain.
"MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability"
https://en.wikipedia...idase_inhibitor
MAO-B inhibition reduces the breakdown mainly of dopamine and phenethylamine https://en.wikipedia...idase_inhibitor
MAO-A inhibition reduces the breakdown of primarily serotonin, norepinephrine, and dopamine;
...
After some further research, co-enzyme B2 seems like the most viable approach aside from SIRT1 activation:
Sources for further reference
https://www.reddit.c...amazing_if_you/
https://forums.phoen...ve-stress.1772/
B2 seems to be crucial for BH4/BH2 cycles:
http://www.katepowe....cle-700x414.jpg
This is really the best simplified graphic I ever found which may help explain a lot of things
MAO-A inhibition reduces the breakdown of primarily serotonin, norepinephrine, and dopamine;