Adaptal looks pretty interesting, its also dirt cheap so worth giving a try.
Here we go:
Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(2):45-9.
[Adaptol in the treatment of anxiety disorders in children with school maladaptation]
[Article in Russian]
[No authors listed]
Abstract
We examined 336 children, aged 7-14 years, with signs of school maladaptation (SM). Anxiety disorders were found in 167 (49.7%), including generalized anxiety disorder - 87 children (25.9%), phobic disorder - 40 children (11.3%), anxiety disorder - 14 (4.2%), social anxiety disorder - 26 (7.7%). These indices differed significantly from those in the comparison group of children without SM. The children with generalized anxiety disorder were treated with adaptol (1000 mg/d during 30 days). The clinical and psychological examination revealed the high efficacy of this drug. Adaptol was well-tolerated, with no side-effects observed.
Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(8):45-8.
[Adaptol in the treatment of ADHD.]
[Article in Russian]
Chutko LS, Surushkina SIu, Nikishena IS, Iakovenko EA, Anisimova TI, Sergeev AV.
Abstract
Effectiveness of adaptol, a non-benzodiazepine tranquilizer, in the treatment of ADHD has been studied. The use of adaptol in dosage 500 mg 2 times daily during one month resulted in the decrease of hyperactivity and impulsivity and did not exert any influence on attention and reaction time. The authors emphasize the importance of this fact due to its relation to side-effects which are often seen in the treatment with benzodiazepine tranquilizers. It has been concluded that adaptol may be used in the treatment of ADHD as a monotherapy in cases with predominance of hyperactivity/impulsivity and as a complex therapy in other diseases especially in the combination of ADHD and anxiety disorders.
Farmakol Toksikol. 1988 Jan-Feb;51(1):21-3.
[Clinical and experimental validation of the use of the tranquilizer mebikar as a corrective of the neuroleptic syndrome]
[Article in Russian]
Zimakova IE, Semenikhin DG, Karpov AM, Kirshin SV.
Abstract
The results of the experimental and clinical studies showed that administration of mebikar in combination with neuroleptics reduced the degree of side effects of the neuroleptics without decreasing their antipsychotic effect.
[Evaluation of the nootropic effect of mebikar in clinical practice]
[Article in Russian]
Zimakova IE, Makarchikov NS, Karpov AM.
Abstract
Mebicar therapy resulted in a reduction of the degree of deficient disorders of thinking in 27 of 50 patients with paranoid schizophrenia and normalization of indices of mental working capacity, attention and memory, shortening of the time of visual-motor disjunctive reaction in 50 patients with borderline states. Mebicar was shown to possess a nootropic effect which differs qualitatively from that of piracetam.
[Effect of tranquilizers on the course of myocardial ischemia and on myocardial resistance to hypoxia in coronary artery occlusion]
[Article in Russian]
Kovalev GV, Gurbanov KG, Tiurenkov IN, Naĭdenov SI.
Abstract
It was shown that meprobamate and phenazepam protect the myocardium from hypoxia and decrease myocardial ischemia during coronary occlusion. Phenibut and mebicar reduce the tolerance to ischemia and increase the degree of ischemic injury to the heart. Diazepam has no effect on these processes.
[Effect of tranquilizing agents on the blood level of endogenous ethanol in alcoholics]
[Article in Russian]
Burov IuV, Treskov VG, Drozdov ES, Kovalenko AE.
Abstract
Experiments on alcohol addicts blood were made to study the time course of the endogenous ethanol level after a single administration of mebicar (1.5 g), a derivative of bicyclic bisuria, 50 ml of 5% sodium hydroxybutyric syrup, a derivative of gamma-hydroxybutyric acid, and 20 mg diazepam, a derivative of 1,4-benzodiazepines. The clinical effect was recorded simultaneously. It was established that different tranquilizers stimulate the increase in the endogenous ethanol level as regards the spectrum of psychotropic activity. This effect was the most pronounced with mebicar and to a less measure with diazepam.
[Comparative analysis of the behavioral, neurochemical and autonomotropic effects of mebikar and diazepam]
[Article in Russian]
Zimakova IE, Kirshin SV, Kamburg RA.
Abstract
It has been shown that the tranquilizers, diazepam (a 1,4-benzodiazepine derivative) and mebicar (a derivative of bicyclic bisureas) produce one-line inhibition of the production of the conditioned reflex of active avoidance in rats and of their "open-field" motor activity. Both the drugs change the balance of neuroactive amino acids in the animals' brain. However they produce different changes: diazepam increases the content of asparaginic and glutamic acids, while mebicar raises that of gamma-butyric acid. No interrelationship was found between psychotropic and vegetotropic effects of the tranquilizers.
Farmakol Toksikol. 1982 Jul-Aug;45(4):16-9.
[Protective effect of the psychotropic preparations diazepam, sodium oxybutyrate and mebikar in experimental arrhythmias]
[Article in Russian]
Kamburg RA, Zimakova IE.
Abstract
It was shown that the psychotropic agents diazepam (1-2 mg/kg), sodium hydroxybutyrate (50-100 mg/kg) and mebicar (250-500 mg/kg) exert a protective action in experimental arrhythmias. This effect is determined by the ability of the drugs to reduce intoxication phenomena, as well as by their antihypoxic and stress-protective properties. On the other hand, the drugs exert an antiarrhythmic effect proper, interfering with potassium ion balance. The protective effects of diazepam, sodium hydroxybutyrate and mebicar enable their application in combined therapy of arrhythmias of varying genesis.
[GABA-ergic component in the action of the tranquilizing agent mebikar]
[Article in Russian]
Kirshin SV, Zimakova IE.
Abstract
The paper is concerned with studies into the effect of the tranquilizer mebicar, a derivative of tetra-N-alkyl bicyclic bisureas, on the GABA-ergic system. The drug in doses of 250-1500 mg/kg (1/15-1/2 LD50) increased the preconvulsive period upon thiosemicarbazide administration, inconsistently changed the effects of picrotoxin and displayed antagonism in regard to bicucullin. Upon 2-week administration the drug reduced the GABA content in the rat brain. A hypothesis is advanced of mebicar-associated facilitation of the inhibitory GABA-ergic transmission.
Edited by medievil, 04 September 2010 - 12:25 AM.