Would a smaller dose have an effect?
Isn't there a synergistic effect between L-Tyrosine and DLPA?
I am a little worried about that anxiety. We'll see.
I will take this when i wake up and a couple of hours after lunch.
Thank you.
There is a synergistic effect between Tyrosine and DLPA in two respects. One, L-Phenylalanine is the precursor to L-Tyrosine, which in turn is the pre-cursor for L-Dopa -> Dopamine -> Epinephrine -> Norepinephrine. Secondly, DLPA (either isomer) can be converted into phenethylamine, which at high levels can increase the release of catecholamines (i.e. neurotransmitters from tyrosine). However, this effect really also depends on the activity of monoamine oxidase B which degrades PEA.
Start out with a smaller dosage and work your way up to where you feel the effects but do not have excessive levels of anxiety.
Do you think I would be better off with a precursor that does cross the blood/brain barrier? L-glutamine maybe?
L-Glutamine is usually either converted to Glutamate (the excitatory neurotransmitter) or is used by the brain as an energy source when glucose is deficient. Your unlikely to experience any real noticeable effects when supplementing with L-Glutamine since it is the most abundant amino acid in your body and is primarily taken up by muscular system (although, it is not know to what degree).
If you want a GABergic effect, you are best to take modified molecules such as Phenibut which are very similar to GABA but can cross the blood brain barrier very effectively. Phenibut itself is very similar in structure to both GABA and phenethylamine, so it's two main proposed mechanisms of action are: enhancing GABergic neurotransmission directly via agonism of receptors, or antagonism of phenethylamine, which in turn may result in GABAergic effects.