Thanks for your replies, but it's a little bit late for me, since i'm not on RIMAs (moclobemide) or MAOIs (selegiline) anymore. Moclobemide made me lazy after two months, Selegiline lost its effectiveness and caused muscle twitches after three months. But the latter is a perfect creativity enhancer.
In Hungary - where I live - there's no perscripton amphetamine available, only street amph, which is likely to be a racemic mixture with a maximum of 20% purity, or some RC sold as "speed". There's no street meth in Hungary. Most people don't even know what meth is, maybe from Breaking Bad, heh.
The other option is Ritalin, which works, but the half-life is too short. I would rather try the Daytrana (methylphenidate transdermal patch), which isn't available.
But these guys are classical, monoaminergic stimulants, and I'd like to avoid them.
Wellbutrin seems effective and well-tolerated, but I'm concerned about the nicotine receptor antagonist properties and its supposed downstream neurotoxicity.
Bupropion caused mitochondrial cytochrome c release and activated caspases 9, 8, and 3 in a time-dependent manner. The reduction in cell viability was significantly inhibited by a caspase 3 inhibitor. Bupropion also induced the mRNA expression of the death receptors DR4 (TRAILR1) and DR5 (TRAILR2). However, bupropion did not increase the level of cellular oxidative stress. Taken together, our data indicate that bupropion activates caspase 3 through the induction of endoplasmic reticulum stress responses and activation of JNK, and consequently induces apoptotic cell death in SH-SY5Y cells.
http://www.sciencedi...300483X11000746
Other options: Phenylpiracetam, Coluracetam, Modafinil, maybe PRL-8-58. What do you think?
Edited by knockout_mice, 04 May 2014 - 08:03 AM.