Many people are aware that nicotine appears to substantially increase cognitive performance in some areas such as fine motor skills and increasing iq by a few points. A major downside to using nicotine is the vasoconstrictive effect it has throughout the body including the brain which could have a negative effect on cognition, depending on other physiological factors that differ between subjects.
Cinnerazine is used for preventing motion sickness and has these properties:
Cinnerazine is a t-type calcium channel blocker improving blood flow to the brain without affecting the heart:
Blocking t-type channels maybe useful against epilepsy (and consequently for sub-clinical neuronal hyperexcitability):
Some more facts on cinnerazine side effects:
Unfortunately cinnerazine and its metabolites appear to cause parkisonism by binding to D-2 dopamine receptors and blocking presynaptic uptake, counterindicating it as a long term nootropic. However, nicotine and/or cotinine seem to protect against Parkinson's by having an opposing effect on dopamine in the brain:
A combo of piracetam and cinnerazine is used in Russia to treat cerebral insufficiency, supposedly synergising the effect of blood thinning and cerebro-vasodilation to support the brain.
I take half a tablet (25/2=12.5mg) cinnerazine and put half a fragmented nicotine lozenge under the tongue. Mostly often I do this in the evening. Other forms of nicotine administration, barring smoking, are obviously fine as well. The mild anticholinergic and antihistaminergic effects of cinnerazine help me sleep a little better as well. Those effects only become obvious when the energizing effect of the nicotine wears off. It's a great combo.