Hello folks
Its been years that im trying to find the best molecule for my needs, and it still eludes me
long story short, im looking something to motivate me in life
i pass the days doing almost nothing, feel no drive, no reward, nothing really interests me.
i have a bit of memory impairment, concentration issues, brainfog etc. not feeling melanchonic or anything thou
im at a point in life where this has to stop and, despite trying hard, i cant push myself out of the situation
i dont feel im particularly sad or anything, but i might certainly be depressed.
my shrink thinks its dysthimia and i tend to agree, probably with a bit of ADD inattentive
we tried many different meds but they all had annoying side effects or were not working or didnt quite hit the spot.
i also had used fluoxetine (prozac) years back, and it had ruined my sexuality in a semi permanent fashion
with this i mean that i have only recently (about two years ago) started to get better. after 7 years of discontinuing.
thats to say that i dont really want to try any SSRI again. if ever, then with a concomitant "antidote".
ritalin does not really work for me and only makes me a bit agitated.
anyhow, ive had decent success with the antidepressant Moclobemide (Aurorix), which is a reversible MAO-A. the issue is that it must be dosed very often, and it kinda did not really motivate me to do things, but did give energy and put me in a better mood. So due to my positive reaction to monoamine oxidase inhibition, ive come to the conclusion that Selegiline or Rasagiline are the next step for my sort of "anergic, atypical disthymia"
Ive been reading up on the two and trying to figure out whats the difference, but i cant make any sense of it:
my understanding is that Selegiline metabolizes to amphetamine derivatives and as such inherently has a certain "neurotoxic" activity; whereas rasagiline metabolizes to aminoindan which has intrinsic neurotrophic effects per se.
to me it seems that rasagiline is vastly less studied for scenarios that vary from parkinson.
on this website https://www.selegiline.com/ there is a lot of condensed information about selegiline with according studies. some of these i found very interesting and tempting. for example:
" Selegiline has immune-system-boosting and anti-neurodegenerative effects. Its use increases the level of tyrosine hydroxylase, growth hormone, cerebral nitric oxide and the production of key interleukins. "
especially the increase of growth hormone is something i would very much appreciate. Does anyone know if rasagiline has this property too?
A critical review of evidence for preclinical differences between rasagiline and selegiline
https://www.scienced...210533612000597 ---> this seems a good paper but i dont have access to the full version
TLDR:
how do the two compare? which one is best (and why) for anergic disthimia?
Edited by magniloquentc0unt, 29 May 2018 - 02:25 PM.