Interesting one to test:
https://patents.goog...0190008883A1/en
these swiss folks have a strong academic track record
Edited by stefan_001, 22 January 2019 - 07:46 AM.
Posted 22 January 2019 - 07:45 AM
Interesting one to test:
https://patents.goog...0190008883A1/en
these swiss folks have a strong academic track record
Edited by stefan_001, 22 January 2019 - 07:46 AM.
Posted 23 January 2019 - 05:14 AM
intersting, combining NR with a mitophagy inducer
In laboratory studies, urolithin A was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging.[15] This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).[15]
by the way ellagic acid breaks down into urolithin A, so perhaps that might be a great addition to an NR protocol
Urolithins, such as urolithin A, are microflora human metabolites of dietary ellagic acid derivatives that are under study as anti-cancer agents.[21] Claims that ellagic acid can treat or prevent cancer in humans have not been proven.[22]
Edited by Phoebus, 23 January 2019 - 05:28 AM.
Posted 23 January 2019 - 08:34 AM
Thanks for posting this Stefan, interesting find! For readers that have missed the Urolithin threads and want to read up on it I post a link to one here.
Most days I drink a glass of 100% pomegranate juice . I will now start to take it simultaneously with my NR.
https://www.longecit...y-fight-ageing/
Posted 23 January 2019 - 12:38 PM
There appears to be synergies with NR an Urolithin A in enhancing autophagy in general and mitophagy in particular through activating the AMPK pathway (the same pathway as calorie restriction).
It has been shown that SIRT1 activates AMPK, and as we know NR is an essential cofactor for sirtuins.
"SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function" (2013) https://www.ncbi.nlm...les/PMC3545644/
There is also evidence that urolithins activate AMPK.
"Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms" (2013) https://www.ncbi.nlm...les/PMC5015040/
Autophagy induction with liposomal trehalose works by activating the same AMPK pathway, as discussed in this thread.
Posted 23 January 2019 - 12:56 PM
Here's more support that urolithin A activates AMPK.
Edited by Fafner55, 23 January 2019 - 12:57 PM.
Posted 23 January 2019 - 03:51 PM
I'd buy that today if it were available. I'm been looking for an affordable source of Urolithin A for some time now. Barring that, a source for gordonibacter urolithinfaciens.
Posted 19 June 2019 - 10:34 AM
Nestlé Health Sciences has struck license agreements with both Chromadex (NR) and Amazentis SA (that is producing the oral Urolithin A and is behind the recent publications on mitophagy in humans).
Nestlé will probably put both molecules in their supplemental drinks (or NR in a snack bar/powder form if they cannot solve the instability problem with NR in solution) to combat sarcopenia in the elderly as well as cognitive decline and other conditions. Interesting times.
Here is Amazentis SA pop-science site on Urolithin A with pressreleases and as a bonus, a video of scientist John Auwerx handling a pomegranate:
Edited by Fredrik, 19 June 2019 - 11:27 AM.
Posted 19 June 2019 - 02:39 PM
Nestlé Health Sciences has struck license agreements with both Chromadex (NR) and Amazentis SA (that is producing the oral Urolithin A and is behind the recent publications on mitophagy in humans).
Nestlé will probably put both molecules in their supplemental drinks (or NR in a snack bar/powder form if they cannot solve the instability problem with NR in solution) to combat sarcopenia in the elderly as well as cognitive decline and other conditions. Interesting times.
Here is Amazentis SA pop-science site on Urolithin A with pressreleases and as a bonus, a video of scientist John Auwerx handling a pomegranate:
The question is, will it be a prescribed drug, or a supplement?
If drug, we aren't going to see this for awhile.
Posted 19 June 2019 - 02:44 PM
The question is, will it be a prescribed drug, or a supplement?
If drug, we aren't going to see this for awhile.
It will be a dietary supplement according to the pressrelease. The medicinal nutrition product may be prescribed (less costly) by a dietitian like myself, or bought without a prescription.
The optimal dose of Urolithin A was 1000 mg in their study. Expecting a combined NR/UA capsule and perhaps a NR/UA powder with creatine if they follow through with the ideas in the patent. We´ll see.
"Nestlé Health Science will take an equity stake in Amazentis and receive global rights to use Amazentis’ patented Urolithin A technology for dietary supplements, select foods and beverages, and medical nutrition products. "
http://pdf.amazentis...pril_2_2019.pdf
Edited by Fredrik, 19 June 2019 - 02:53 PM.
Posted 19 June 2019 - 02:56 PM
Excellent. I'd love to get access to that right now.
Any rumors on when it might become available?
Posted 20 June 2019 - 07:30 PM
Excellent. I'd love to get access to that right now.
Any rumors on when it might become available?
go to the link and sign up for an email notificiation, thats what I did
It will be a dietary supplement according to the pressrelease. The medicinal nutrition product may be prescribed (less costly) by a dietitian like myself, or bought without a prescription.
The optimal dose of Urolithin A was 1000 mg in their study. Expecting a combined NR/UA capsule and perhaps a NR/UA powder with creatine if they follow through with the ideas in the patent. We´ll see.
"Nestlé Health Science will take an equity stake in Amazentis and receive global rights to use Amazentis’ patented Urolithin A technology for dietary supplements, select foods and beverages, and medical nutrition products. "
why creatine though? What does that add to the mix?
Posted 21 June 2019 - 01:49 AM
why creatine though? What does that add to the mix?
Posted 11 August 2019 - 09:46 PM
Posted 12 August 2019 - 06:28 AM
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