Hi Mike, & your approach to longevity appears quite admirable. Designing the ultimate stack to achieve coverage of all these angles may be complicated, due to interactions and possible downside risk of poly-supplementation with multiple cellular-modulating agents. My knowledge of cellular physiology and the effects of combination supplemental therapies isn't up to the task of figuring this all out, but I would look to the boffins who've spent their lives studying these things for perhaps the best guidance. David Sinclair, Chris Masterjohn, Ray Peat, SelfHacked, etc. Even these guys (many of them PhDs) don't agree on how best to mix & match supplements, lifestyles & nutrition for optimal effect.
One of my "No-Brainer" approaches to multiple aspects of the aging & longevity issue is Iron Homeostasis aka controlling "Ferrotoxic Disease". I've got a collection of links on this here:
https://www.longecit...isease-omnibus/
If you dig into the weeds of this issue, you'll see:
Fenton Chemistry associated with Free/Labile iron is responsible for 60-70% of cellular DNA damage: https://en.wikipedia...l_damage_to_DNA
Iron acts as a catalyst for lipid oxidation of cellular membranes, proteins & myelin sheaths of neurons: https://nanopdf.com/...d-oxidation_pdf
Iron deposits are a universal finding in brain tissue of Alzheimer's patients: https://www.ncbi.nlm...les/PMC6139360/
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What I like best about the Iron Homeostasis angle of longevity, is that it doesn't involve intense exercise, a Spartan diet or complex supplement protocols. Regular whole blood donation (2-3 times/year) and a few chelators (Quercetin, Curcumin & IP6/Inositol Hexaphophate) are all it takes to greatly reduce the effects of age related Ferrotoxic Disease. I tend to rant & rave about this "theory", but I've actually seen remarkable results in my own life. I started donating blood in my 30s (7 gallons over the years), and now in my mid 60s, I enjoy remarkable health, this despite my rather dreadful habits of red meat, beer & wine, & exercise avoidance.
I wish you well in your quest for the ultimate stack, but in the meantime, there is an easy work-around for many aspects contributing to aging and disease. Get thee to a blood bank! The life you save may be your own!
Edited by Dorian Grey, 19 January 2020 - 04:12 AM.