LEF has a new tweaked out CoQ10. What do you guys think?
http://www.lef.org/n.../item00952.html
http://www.lef.org/m...rt_coq10_01.htm
Posted 20 November 2006 - 07:04 AM
Posted 22 November 2006 - 03:58 AM
Posted 22 November 2006 - 05:40 AM
Personally, I'll stick with mtioQ,
Posted 24 November 2006 - 06:49 AM
Posted 24 November 2006 - 03:20 PM
Posted 24 November 2006 - 05:15 PM
Posted 24 November 2006 - 05:45 PM
Posted 24 November 2006 - 05:50 PM
Posted 24 November 2006 - 06:14 PM
The effects of lifelong ubiquinone Q10 supplementation on the Q9 and Q10 tissue concentrations and life span of male rats and mice.
Lonnrot K, Holm P, Lagerstedt A, Huhtala H, Alho H.
Laboratory of Neurobiology, University of Tampere, Medical School, Finland.
The effect of lifelong oral supplementation with ubiquinone Q10 (10 mg/kg/day) was examined in Sprague-Dawley rats and C57/B17 mice. There were no significant differences in survival or life-span found in either rats or mice. Histopathologic examination of different rat tissues showed no differences between the groups. In Q10 supplemented rats, plasma and liver Q10 levels were 2.6 to 8.4 times higher at all age points than in control rats. Interestingly, in supplemented rats the Q9 levels also were significantly higher (p<0.05) in plasma and liver at ages 18 and 24 months. Neither Q9 nor Q10 levels were affected by supplementation in kidney, heart, or brain tissues. In spite of the significant changes in plasma and liver ubiquinone concentrations, lifelong Q10 supplementation did not prolong or shorten the lifespan of either rats or mice.
PMID: 9584986 [PubMed - indexed for MEDLINE]
Edited by velopismo, 24 November 2006 - 06:24 PM.
Posted 24 November 2006 - 06:25 PM
Posted 24 November 2006 - 06:57 PM
Ubiquinol profoundly impacted and prolonged running time 150 fold vs. placebo in aged female rats.
Posted 24 November 2006 - 06:58 PM
So for LEF new CoQ10, if you are not a member and pay 600.00 for 10 bottles, we are talking a 1.20 per day supplement (2 caps). I know many people take CoQ10. Based on the available evidence, is it worth that much? Or do you guys have some cheaper sources for the supp?
Posted 24 November 2006 - 07:10 PM
Posted 24 November 2006 - 07:14 PM
Don't buy LEf stuff. Not that quality is bad, most of it is probably OK. However too pricey mostly. Go to e.g. iherb.com (no commercial interest) and get e.g. Now brand, or jarrow brand, etc. For coenzyme Q-10 you want stuff e.g. in gelcaps with oil. 100 mg/day is PLENTY.
Posted 24 November 2006 - 07:16 PM
It has made a big difference in my endurance (not sure how widespread this effect is, but reproducible in me).
Although coenzyme Q10 supplementation has improved exercise tolerance in some individuals with mitochondrial encephalomyopathies (see Deficiency) (26), there is little evidence that it improves athletic performance in healthy individuals. At least 7 placebo-controlled trials have examined the effects of 100-150 mg/d of coenzyme Q10 supplementation for 3-8 weeks on physical performance in trained and untrained men. Most found no significant differences between groups taking coenzyme Q10 and groups taking placebos with respect to measures of aerobic exercise performance, such as maximal oxygen consumption (VO2 max) and exercise time to exhaustion (57-61). One study found the maximal cycling workload to be slightly (4%) increased after 8 weeks of coenzyme Q10 supplementation compared to placebo, although measures of aerobic power were not increased (62). Two studies actually found significantly greater improvement in measures of anaerobic (60) and aerobic (61) exercise performance after supplementation with a placebo compared to coenzyme Q10. Studies on the effect of supplementation on physical performance in women are lacking, but there is little reason to suspect a gender difference in the response to coenzyme Q10 supplementation.
Since when it causing rats to live longer the endpoint for taking a supp?
Posted 24 November 2006 - 07:53 PM
Posted 24 November 2006 - 07:59 PM
Posted 25 November 2006 - 11:48 AM
This thread has gotten silly. Since when it causing rats to live longer the endpoint for taking a supp?
Don't buy LEf stuff. Not that quality is bad, most of it is probably OK. However too pricey mostly. Go to e.g. iherb.com (no commercial interest) and get e.g. Now brand, or jarrow brand, etc. For coenzyme Q-10 you want stuff e.g. in gelcaps with oil. 100 mg/day is PLENTY.
Now Foods, CoQ10, 100 mg, 150 Softgels
SRP: $79.99
Our Price: $46.19
which equals 30.8cents/day.
Is co-q10 the most important supp, or top 3. Nope. But it is one I recommend. It has made a big difference in my endurance (not sure how widespread this effect is, but reproducible in me). Also very important for gum health, though I would take some even without these issues.
Price has come way down since japanese monopoly has been broken. Which is why there is suspicion on new propriatery (sp?) form to keep raking in the profits.
Posted 25 November 2006 - 11:51 AM
I have not looked closely at CoQ10. Why are ImmInst members taking this supplement?
Posted 25 November 2006 - 10:01 PM
This thread has gotten silly. Since when it causing rats to live longer the endpoint for taking a supp?
Don't buy LEf stuff. Not that quality is bad, most of it is probably OK. However too pricey mostly. Go to e.g. iherb.com (no commercial interest) and get e.g. Now brand, or jarrow brand, etc. For coenzyme Q-10 you want stuff e.g. in gelcaps with oil. 100 mg/day is PLENTY.
Now Foods, CoQ10, 100 mg, 150 Softgels
SRP: $79.99
Our Price: $46.19
which equals 30.8cents/day.
Is co-q10 the most important supp, or top 3. Nope. But it is one I recommend. It has made a big difference in my endurance (not sure how widespread this effect is, but reproducible in me). Also very important for gum health, though I would take some even without these issues.
Price has come way down since japanese monopoly has been broken. Which is why there is suspicion on new propriatery (sp?) form to keep raking in the profits.
May I disagree?
Which delivery form NOW foods uses in its product? I bet that it is not a liposomal delivery. According to the CoQ10 studies I have read in the past, the ideal dose of CoQ10 is 2-300mg/day, split in 2-3 doses. And this is for LIPOSOMAL coQ10, the form used in research studies (Not sure if MitoQ is of this kind but i believe so).
Powders and various oily delivery have an effectiveness on blood serum levels of 1/5 to 1/10 of the form used in clinical studies.
Your figure, Scott, woudl be:
2 x $0.308 x 5 = $3.08 /day - CoQ10 benefits are not worth this much.
I stick with the tiny 30mg dose included in my multi since anecdotal reference shows some effect of even such doses of CoQ10 ranging from 30 to 100mg, that most people take.
I have no perosnal interest in LEF or in ANY other supplement company, but if the bioavailability claims are meet (i.e further studies confirm that), LEF ubiquinol would currently be the most cost-effective product of this kind, at 1 cap/day.
BTW, anyone knows about half life of ubiquinol? I'm pretty sure CoQ10 should be taken at least in 2 separate doses in a day.
Posted 25 November 2006 - 10:36 PM
Posted 26 November 2006 - 04:35 AM
I have not looked closely at CoQ10. Why are ImmInst members taking this supplement?
CoQ10 benefits IMHO are not related to lifespan increasing. Main benefits are twofold:
1) kidney protection
2) energy improvement
Both of which improve the quality of life.
I dont have references at hand but I think you should find something looking into pubmed.
Posted 26 November 2006 - 12:20 PM
I'll comment just on conventional coenayme Q10:
LEF has some good information, and lots of hype.
Powders are not well absorbed--I agree.
There are many many different companies each with their own proprietary better absorbed form of coenzyme Q-10. If you can show me comparisons among any of these, I am certainly willing to look i.e. I know any of them will be better then powder, is there any evidence that any are better then any others, or any are better then powder in an oil base?
"the ideal dose of CoQ10 is 2-300mg/day, split in 2-3 doses"
Ideal dose for what? that is a ton. Are we speaking of diabetics or people with heart failure?
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