I'm curious, because black pepper has quite a bit of bioprene?
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Advocacy & Research for Unlimited Lifespans
Posted 19 May 2007 - 03:28 AM
Posted 19 May 2007 - 01:28 PM
Posted 19 May 2007 - 04:53 PM
Posted 19 May 2007 - 05:04 PM
Posted 19 May 2007 - 05:22 PM
And what about grapefruit? I think (but not sure) there are a lot more substances we consume every day affecting P450 enzymes we are not aware of.
Posted 19 May 2007 - 05:29 PM
Posted 19 May 2007 - 05:33 PM
And what about grapefruit? I think (but not sure) there are a lot more substances we consume every day affecting P450 enzymes we are not aware of.
Pomegranate, resveratrol, and quercetin to name a few.
Posted 19 May 2007 - 06:49 PM
And what about grapefruit? I think (but not sure) there are a lot more substances we consume every day affecting P450 enzymes we are not aware of.
Pomegranate, resveratrol, and quercetin to name a few.
I have a recent experience with a drug that starts me to believe that ashwagandha could be a culprit as well, but I could not find any evidence of it yet.
Posted 19 May 2007 - 06:53 PM
Posted 19 May 2007 - 07:30 PM
And what about grapefruit? I think (but not sure) there are a lot more substances we consume every day affecting P450 enzymes we are not aware of.
Posted 19 May 2007 - 07:45 PM
And what about grapefruit? I think (but not sure) there are a lot more substances we consume every day affecting P450 enzymes we are not aware of.
grapefruit does have to be avoided when taking certain drugs.
Posted 19 May 2007 - 08:06 PM
Posted 19 May 2007 - 08:20 PM
I found this study:
http://www.pubmedcen...i?artid=1062157
So, I need not worry to much about it I guess but be alert as ever. I did stop this medication anyway.Our results suggest that Withania root is basically a monofunctional inducer that increases the activity of mainly phase II enzymes and has little effect on phase I monofunctional oxygenases, which is also supported by earlier studies (15). Our data show that Withania root has little effect on the cyt P450 system.
Posted 19 May 2007 - 08:44 PM
I don't avoid bioprene any more than I avoid any of the other of the billion-billion substances that I don't go out of my way to flood my system with.
No I don't avoid black pepper, nor do I attempt to consume tremendous quantities of it daily.
Posted 19 May 2007 - 11:20 PM
Posted 19 May 2007 - 11:53 PM
Posted 20 May 2007 - 12:18 AM
Posted 20 May 2007 - 12:25 AM
The biggest issue with Piperine in that it inhibits liver and intestine enzymes whereas the fruits like pomegranate inhibit the intestine CYPs. This actually makes the fruits protective.
Posted 20 May 2007 - 12:30 AM
Why does this make the fruits protective?
Decreased presystemic oxidation by this CYP increases the systemic bioavailability of drug substrates and the likelihood of drug toxicity. Dietary interactions may complicate drug therapy but inhibition of certain CYP reactions may also protect the individual against toxic metabolites and free radicals generated by CYPs. Chemicals in teas and cruciferous vegetables may also inhibit human CYP enzymes that have been implicated in the bioactivation of chemical carcinogens. Thus, food constituents modulate CYP expression and function by a range of mechanisms, with the potential for both deleterious and beneficial outcomes.
Posted 20 May 2007 - 12:36 AM
Why does this make the fruits protective?
From the second paper I cited:Decreased presystemic oxidation by this CYP increases the systemic bioavailability of drug substrates and the likelihood of drug toxicity. Dietary interactions may complicate drug therapy but inhibition of certain CYP reactions may also protect the individual against toxic metabolites and free radicals generated by CYPs. Chemicals in teas and cruciferous vegetables may also inhibit human CYP enzymes that have been implicated in the bioactivation of chemical carcinogens. Thus, food constituents modulate CYP expression and function by a range of mechanisms, with the potential for both deleterious and beneficial outcomes.
Posted 20 May 2007 - 12:47 AM
So CYP is a double edged sword. What makes liver p450 inhibitors different?
I did re-read the pomegranate thread, but I'm still confused about this issue.
Posted 20 May 2007 - 01:08 AM
Posted 20 May 2007 - 01:23 PM
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