Anyone else read this study? Apparently it has prompted AOR to reformulate their selenium product.
http://aor.ca/int/ab...fullarticle.pdf
Posted 21 November 2007 - 10:37 PM
Posted 21 November 2007 - 11:03 PM
Posted 21 November 2007 - 11:38 PM
Posted 22 November 2007 - 04:47 AM
They haven't reformatted Ortho-Core... Still 200ug in the full 9 capsule dose.Anyone else read this study? Apparently it has prompted AOR to reformulate their selenium product.
Posted 22 November 2007 - 08:08 AM
Edited by brainbox, 22 November 2007 - 08:12 AM.
Posted 22 November 2007 - 08:52 AM
So the evil government of Germany wasn't so evil after all in making selenium a prescription drug?
Edited by markymark, 22 November 2007 - 08:53 AM.
Posted 22 November 2007 - 02:47 PM
Posted 22 November 2007 - 07:28 PM
Edited by krillin, 22 November 2007 - 07:32 PM.
Posted 22 November 2007 - 07:34 PM
Time to revise my calculation, based on the blood results from that article. I had earlier assumed that a 200 mcg supplement would raise blood levels by 80 ng/ml, because 100 mcg raised it by 40 ng/ml in SU.VI.MAX. (PMIDs 16115341 and 11718454) But Figure 1 shows that it only went up by about 70 ng/ml.
Looking at the selenium cancer study (PMID: 12101110), it's best to get more than from diet, since the lowest baseline tertile plus 200 mcg was best, followed by middle tertile plus 200 mcg, followed by highest tertile plus placebo. Thus, the maximum desirable blood level would be 105.2 ng/ml + 70 ng/ml = 175.2 ng/ml.
NHANES III found that Americans ate an average of 106 mcg and had an average of 124 ng/ml in plasma.
http://books.nap.edu...i...10&page=309
http://books.nap.edu...i...10&page=310
Increasing that to a maximum of 175.2 ng/ml means adding no more than 128 mcg supplemental selenium (assuming +40 ng/ml for every 100 mcg eaten, since we're taking a dose closer to 100 than 200). Taking only 100 mcg/day gives a reasonable safety margin.
Posted 22 November 2007 - 07:42 PM
What I would like to see is the distribution of selenium blood levels in both groups.
But Figure 1 shows that it only went up by about 70 ng/ml.
Posted 22 November 2007 - 07:56 PM
I've been looking with my eyes shut this morning apparently.... thanks.
Posted 22 November 2007 - 08:18 PM
Posted 23 November 2007 - 05:07 AM
Hmm. I take 200 mcg. a day in my LEF mix and I have a years' worth of LEF Mix tablets left over from the closeout some months ago. The newly formulated LEF mix tablets still contain 200 mcg. I'd be willing to bet that LEF ignores or counters this study until it's sold out all of its current stock, assuming it's going to change the formulation because of this. They've only changed the formulation about 6 times in 20 years IIRC.
Posted 23 November 2007 - 07:02 PM
Edited by Matt, 23 November 2007 - 07:03 PM.
Posted 23 November 2007 - 09:37 PM
Forget what the research says, just monitor you OWN glucose and insulin levels and go from there!
Posted 27 December 2007 - 03:40 AM
Time to revise my calculation, based on the blood results from that article. I had earlier assumed that a 200 mcg supplement would raise blood levels by 80 ng/ml, because 100 mcg raised it by 40 ng/ml in SU.VI.MAX. (PMIDs 16115341 and 11718454) But Figure 1 shows that it only went up by about 70 ng/ml.
Looking at the selenium cancer study (PMID: 12101110), it's best to get more than from diet, since the lowest baseline tertile plus 200 mcg was best, followed by middle tertile plus 200 mcg, followed by highest tertile plus placebo. Thus, the maximum desirable blood level would be 105.2 ng/ml + 70 ng/ml = 175.2 ng/ml.
NHANES III found that Americans ate an average of 106 mcg and had an average of 124 ng/ml in plasma.
http://www.nap.edu/o...d=9810&page=309
http://www.nap.edu/o...d=9810&page=310
Increasing that to a maximum of 175.2 ng/ml means adding no more than 128 mcg supplemental selenium (assuming +40 ng/ml for every 100 mcg eaten, since we're taking a dose closer to 100 than 200). Taking only 100 mcg/day gives a reasonable safety margin.
Posted 03 January 2008 - 03:00 AM
Posted 14 June 2008 - 10:19 PM
After revamping my diet (no brazil nuts, almost all wheat eliminated), CRON-o-Meter says I get 37.2 mcg. Thus, a daily 200 mcg supplement would bring me just a few mcg over the limit. So I took 200 mcg SeMC daily for three months prior to my blood test. My blood test came back at 150 ng/ml. Substantially more than average, and comfortably less than the limit I imposed. At least something went right for me this year...Time to revise my calculation, based on the blood results from that article. I had earlier assumed that a 200 mcg supplement would raise blood levels by 80 ng/ml, because 100 mcg raised it by 40 ng/ml in SU.VI.MAX. (PMIDs 16115341 and 11718454) But Figure 1 shows that it only went up by about 70 ng/ml.
Looking at the selenium cancer study (PMID: 12101110), it's best to get more than from diet, since the lowest baseline tertile plus 200 mcg was best, followed by middle tertile plus 200 mcg, followed by highest tertile plus placebo. Thus, the maximum desirable blood level would be 105.2 ng/ml + 70 ng/ml = 175.2 ng/ml.
NHANES III found that Americans ate an average of 106 mcg and had an average of 124 ng/ml in plasma.
http://www.nap.edu/o...d=9810&page=309
http://www.nap.edu/o...d=9810&page=310
Increasing that to a maximum of 175.2 ng/ml means adding no more than 128 mcg supplemental selenium (assuming +40 ng/ml for every 100 mcg eaten, since we're taking a dose closer to 100 than 200). Taking only 100 mcg/day gives a reasonable safety margin.
Finally got around to using the CRON-o-Meter and found out that my diet is nowhere near average. 1/4 cup/day of mixed nuts gives me 151.7 mcg of selenium all by itself. Total non-supplement intake is 250.7 mcg. It thus appears that even a smidge of brazil nuts is incompatible with selenium supplementation.
Posted 18 June 2008 - 09:44 PM
Posted 18 June 2008 - 10:34 PM
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