Hi,
Was just wondering if theres any evidence to suggest resveratrol fights cancer?
Have there been any studies or is there any evidence to show that it helps combat cancer?
If anyone can post any info AT ALL on how resveratrol can help fight cancer (specifically liver cancer) i would be EXTREMELY grateful.
Just want to get as much information as possible, as time is running out...
many thanks.
I have done some research on the Hedgehog (Hh) pathway and currently there are three ongoing clinical studies maybe 4. Depending on your grade of cancer the Hh pathway might be of interest to you. The Hh pathway is basically like a gas pedal for cancer. For us cancer researchers the grade of the cancer is very often dependent on Hh pathway activation (the Hh pathway is like a master switch for growth factors like EGFR, VEGF). The more the Hh pathway is turned on the worse the grade of cancer is. This has been studied with colon, pancreatic, breast, prostate, liver, gliomas, medulloblastoma, small cell lung cancers... ect this list goes on... Anyways to make a long story short there are a few natural inhibitors of this pathway.
- Cyclopamine found in corn lillys in the sierra's (California)
- Zerumbone more can be found here (pubmed article)
I'm very familiar w/ cyclopamine and its structure is very different compared to zerumbone.
We have identified several types of naturally occurring inhibitors of GLI-mediated transcription by using a cell-based assay;
different mechanism of action from cyclopamine, which is an inhibitor of Smo.
This is very BIG statement. Won't go into much detail but SMO is upstream in the hedgehog pathway where as GLI is a activator of gene transcription. If you inhibit GLI you don't have to worry about upstream mutations in the pathway. GLI is the most downstream target! Having said all of that we don't really how well zerumbone will diffuse into the cell or even into the nucleus.
more info about zerumbone can be found here
http://zerumbone.com/ A few more articles
Activation of the hedgehog pathway in human hepatocellular carcinomas. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.