I've been taking 2gm of resveratrol for a while (RevGenetics 99% at the moment), and was interested to see them coming out with a micronized form.
In some correspondence with Hedgehoginfo, he mentioned that he had tried mixing his resveratrol with peanut butter, and that he thought that might help it to be absorbed more slowly.
I've been doing that, and I can say that the RevGenetics 99% stuff has no bitter flavor for me. When mixed into creamy peanut butter, it disappears within a few seconds. The only danger is that I may eat too much peanut butter!
So my questions:
- Is the resveratrol dissolving in the peanut oil?
- Is the peanut butter treatment likely to increase total absorption?
- How do you think this compares with taking micronized resveratrol in capsule form?
My assumption is that you would either go micronized or use something like peanut butter or miralax (which sounds kind of distasteful to me).
What are your thoughts on the best way to increase absorption and maximize effectiveness?
Yes, any oil, including peanut oil in peanut butter, will dissolve resveratrol.
Other non-hydrscopic supplements (CoQ10, eg_ show superior bioavailabiliyt and higher blood serum levels when dissolved in oil.
this should be superior to micronized resveratrol in a capsule.
Micronization helps when using a dispersant to mix resveratrol into a water-based liquid. If it dissolves into oil, no difference. Microniation will also help if using cyclodextrins to make a water soluble form of resveratrol.
At this time, I believe I get the most effect from resveratrol using milk protein to bind to and dissolve it; milk, chocolate milk, yogurt with lots of stirring, or sour cream wok for me. I use joint paint, or lack thereof, as a measure of nf-KappaB inhibition, as a proxy for relative blood serum levels.
BTW, I think dissolving resveratrol in a milk protein (whey) solution, then evaporating or spray drying, and encapsulating the powder, would be a very effective delivery mechanism. More so than micronized. Anthony, if you read this, want to work on developing this?