You would get quite strong effects from 10mg! But you don't get these effects immediately. I can take some time until the dose becomes effective - due to the MAO Inhibition effect.
40mg of Selegiline would have strong negative results!
Have you taken the Julab Selegiline today? How many hours is your first ingestion ago?
Experience gained during the development of selegiline reveals that some individuals exposed to doses of 600 mg per day suffered severe hypotension and psychomotor agitation. Since the selective inhibition of MAO-B by selegiline is achieved only at doses recommended for the treatment of Parkinson's Disease (10 mg per day), overdoses are likely to cause significant inhibition of both MAO-A and MAO-B. Consequently the signs and symptoms of overdosage may resemble those observed with non-selective MAO inhibitors. Delays of up to 12 hours between the ingestion of selegiline and the appearance of signs of overdose may occur. Death has been reported following overdoses with non-selective MAO inhibitors. Signs and symptoms of overdose may include dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, hypertension, hypotension and vascular collapse, respiratory depression and failure, rapid and irregular pulse, cool clammy skin, diaphoresis, convulsions and coma.
Cheers
Alex
* Selegine authenticity?
... I recently ordered Selegiline tablets from Julab/Biolab, manufactured in Thailand at 5 mg dosage settings, for its documented uses as a nootropic, for longevity and enhancement of attention and focus.
Upon initial ingestion of a single 5 mg dose to test for potency, and duration of 60 minutes, no effect was noted. Following a timed 120 minute interval and no discernable subjective changes in wakefulness, attention or concentration, one more 5 mg tablet was ingested.
Three hours later to no discernible effect, an additional 10 mg was ingested. There were still no subjective effects. Finally, at six hours post-onset, 10 mg more were ingested. No effects were noted.
At these high dosage ranges -- 30 to 40 mg, subjective effects should be clearly noted after a period of nine hours. I have no tolerance or prior history of stimulant usage, so this should not be a factor in efficacy. I'm interested in learning if there is some misconception of the effects of this nootropic, or if the manufacturer may be supplying placebo pills in place of the actual formulation. Any insights would be appreciated ...