SRT501 is 5 times more bioavailable than resveratrol alone...It is my understanding that Resveratrol + Tween 80 is more bioavailable than SRT 501 and it is available today without a prescription? Am I correct? If so, is there a need for SRT 501?
I was under the impression that Resveratrol + Tween 80 increased absorption, not bioavailability. What's important is the systemic effect on Sir2/SIRT1.
The distinction may be somewhat moot; there is a limit to blood serum levels that can be attained from oral ingestion, unless resveratrol is micronized and delivered via a vehicle such as tween80 or HPMC, which increases the upper bound. If it doesn't get into the blood, it's not going to be available. "Five times" may be a somewhat optimistic number.
Enhancing the amount that is absorbed by cells once it gets into the blood is another matter; some seek to slow down its metabolization by blocking glucuronidation or sulfonation with piperine, quercetin or most effectively with luteolin. There is no definitive answer as to whether these strategies actually enhance resveratrol's effects. They might, but some people (I am one) report negative effects from combining these with resveratrol, possibly due to luteolin and quercetin being powerful anti-aromatases, and possibly being responsible for joint pain (which can be manifest as tendinitis) due to too little estrogen being produced from testosterone (see some of the other threads in this forum.) Resveratrol is a weaker anti-aromatase.
Another wrinkle: the glycon form of resveratrol, polydatin, is converted into resveratrol in the body, and may achieve higher blood levels than from taking resveratrol, probably by bypassing first-pass liver metabolization. Taking the two together may have an additive effect. Hedgehog was measuring this while he had use of a lab, but now has other responsibilities that preclude further research on his part. The preliminary measurements he made indicated much higher serum levels with polydatin.
If anyone wants to experiment with HPMC, luteolin or polydatin, like for a graduate thesis, PM me for information.