Pulled from this ImmInst thread, and from the Calorie Restriction Society digest listserve:
- (#1) We have read the recent news by your colleagues Takashi and Imai at Washington University regarding circadian rhythm, NAD levels, and SIRT1. In your opinion, what is the optimal daily routine in food/exercise and any supportive supplements (resveratrol, niacinamide, etc.) to maximum overall health and longevity? I guess just outline for us what would be your ideal 24 or 48/72 hr routine based on w/e variation you think is necessary.
NAD/NADH Ratio, Nampt, SIRT1 - regulate the body's internal clock
http://www.scienceda...90319142401.htm- (#2) Based on this study, how should a person re-regulate their internal clock or deal with problems like insomnia or jet lag?
- (#3 extension of prior question asked above) What is your opinion of CR, IF and protein on/off days (intermittent protein use to increase intracellular autophagy) as the best approach to diet? What should the total diet composition be in terms of fats/carbs/protein?
- (#4) What's your take on HIIT (High Intensity Interval Training)? Is sustained endurance runs better for overall health? What is the best exercise/workout routine?
- (#5) Calorie Restriction has very good protective effects against diabetes, stroke, heart disease, cancer etc.. Do you see any potential risks from calorie restriction such asinfectious disease. And are you looking into studying CR's effects on the immune system in humans?
- (#6) In your papers on the role of protein intake and IGF-1 in CR, you suggest that the effects of CR might only be experienced if one takes care to keep one's protein intake low. What is your current position on that? Has there been any new research to change your opinon?
- (#7) What do you think about the claim that in many IF studies the animals are also CR'd because they simply eat less when food availability is restricted? What are the benefits of IF without any CR?
- (#8) Do you think coffee is healthy? It is the most widely consumed beverage in US, it contains acrylamide, etc.
- (#9) I have been practicing calorie restriction, following guidelines of the CR Society and the book The CR Way, for about 22 months now. My primary care physician and now a hematologist are concerned about my low white blood cell count, which gets into the range of 2.17 when I am diligently restricting calories (BMI around 18.5) , and rises into the low 3.x range when I am unable to comply with the CR regimen (BMI around 20). Low end of normal for WBC is considered around 4.0. Prior to CR, my WBC hovered around 4.0, possibly due to my Sjogren's Syndrome.
I know that anecdotally CR practitioners report low WBC and other blood parameter changes. I have explained to my hematologist that low WBC is expected in CR (and is even seen by some as a biomarker of CR), and have pointed her to some of your papers. What appears to be lacking in the literature is a concise peer-reviewed paper that draws on the work with long-term CRed patients to advise physicians of roughly what to expect in a CRed patient. With growing numbers of CR practitioners, the social utility of such a paper is rising. In the absence of such a paper, I may wind up joining the ranks of CRers who've had bone marrow biopsies because their docs are worried about low WBC of unknown origin.
Have I missed a paper of yours that could serve this physician education purpose?
- (#10) How do you suggest a person balance the in-take of antioxidants, vitamins, etc. with exercise/food so that you do not overstimulate/overload (harm) the body?
- (# 11) Which small molecules (OTC/prescription medication) do you recommend (if any) to increase endogenous chaperone mediated autophagy and increase the LAMP-2a receptor activation (an issue noted by Ana-Marie Cuervo, etc.)?
- (#12) I and a colleague here in Rochester, NY, who is also in Dr. Fontana's
study, were tested at WUSTL by Dr. Fontana in 2004. If possible, we'd
like to know when we'll be
retested, approximately. Also, another Rochesterian, Curt Fey, was
added to the study more recently; will he be invited at the same time?
That would be very pleasant.
We all regret that there will be no CR Society meeting this summer,
and hope for better things to come.
Yours sincerely,
-- Saul
- (#13) What about the immune system when doing calorie restriction, how does it affect wound healing etc?
-(#14) What are your opinions about intermittent fasting(eg eating every other day)?
- (#15 ) What about CR and autoimmune diseases, allergies etc?
- (#16) Do you practice CR? If so, do you have any tips on getting started?
-(#17) What are your thoughts on alternate-day fasting (aka intermittent fasting) and variations thereof?
-(18) Do you use CR to try to live long enough for therapies that will create indefinite lifespans?