I show some signs of high copper like being too sensitive and slight paranoiac tendencies ? thought of lowering my copper levels by using vitamim c 1000mg daily but it turns out to lower zinc levels too that may be bad for paranoia. So what are the options taking c vitamin with zinc?
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First, your link (titled: TOXICITY OF TRACE ELEMENTS IN TOBACCO SMOKE) doesn't say that cigarette smoking depletes copper;??????
The article fragment you cited is discussing the pro-oxidative, carcinogenic effects of inhaled metal ions in tobacco smoke. From the article:
"The potential to cause cellular damage by metal ions in conjunction with other constituents of tobacco smoke is enormous. Various studies have demonstrated the role of reactive oxygen species in the toxicity of transition metals, and the presence of many highly reactive metal ions in high concentrations in tobacco smoke indicates a role for metal ions in the subsequent toxicity and carcinogenicity of tobacco smoke."
Inhaled iron, copper, and chromium are implicated in the "production of superoxide anion[s], hydrogen peroxide, and hydroxyl radical[s]"
They go on in the very next breath (as I already cited) to discuss how several other metallic constituents of tobacco smoke induce oxidative stress and deplete GSH.
Some links which substantiate my position, which I thought was immediately obvious from reading the essay you cited:
Inhaled Iron from Cigarettes induces oxidative damage:
http://ajrccm.atsjou...ract/153/4/1353Cigarette smoke contains chromium:
http://www.weitzlux....fhealt_707.htmlInhaled chromium is carcinogenic:
http://www.epa.gov/t...f/chromium.htmlCigarettes contain copper and increases serum copper:
From PMID: 8582658
"Cigarettes contain
copper; moreover, cigarette smoking may alter
copper metabolism through specific cigarette smoking mediated hormonal mechanisms."
http://cat.inist.fr/...&cpsidt=2163571Elevations in serum copper, erythrocytic copper, and ceruloplasmin concentrations in smokers.
Davidoff GN, Votaw ML, Coon WW, Hultquist DE, Filter BJ, Wexler SA.
Previous investigators have reported significant elevations of serum copper and ceruloplasmin levels in lymphoma patients and subjects using estrogen, but have not taken into account the smoking habits of these populations. In order to determine whether smoking had any effect on these variables, the authors examined five groups for serum and erythrocytic copper and ceruloplasmin levels: 40 healthy subjects, 14 users of oral contraceptives, 25 smokers, 14 nonsmoking pretreatment lymphoma patients, and eight treated lymphoma patients. Significant elevations of serum copper and ceruloplasmin in pretreatment lymphoma patients, treated patients, and estrogen users were found, confirming previous reports. In addition, all groups had elevations of erythrocytic copper compared with the healthy subjects. Also, significant elevations of serum copper (P less than .0053) and ceruloplasmin (P less than .0001) were found in smoking relative to nonsmoking subjects. No correlation between duration of smoking and these elevations was found.
PIP: Levels of serum and erythrocytic copper and ceruloplasmin are compared among groups of smoking and nonsmoking individuals, some of whom have taken oral contraceptives 97 subjects were studied. 40 were healthy subjects who were nonsmokers, and 4 users of oral contraceptives, 25 smokers, and 4 nonsmoking pretreatment lymphoma patients, and 8 patients under treatment for lymphoma were also studied. There were elevations of serum copper and ceruloplasmin activity for all 5 groups. By Student's t test, there were elevations of serum copper, erythrocytic copper, and ceruloplasmin in all 4 groups compared with healthy nonsmoking subjects at least at the P.01 level,; it was P.05 for erythrocytic copper smokers. Significant correlations of linear relationship between serum copper and ceruloplasmin were noted for all populations except smokers. No correlation was apparent between duration of smoking, or frequency of usage and elevations of serum copper, erythrocytic copper, or ceruloplasmin.
PMID: 717285 [PubMed - indexed for MEDLINE
High serum copper increases mortality risk:
http://www.ncbi.nlm....t_uids=16570028High serum iron and copper are pro-oxidative:
http://www.springerl...666618q748uh55/Please present a more lucid argument if you disagree with my analysis.
Edited by VespeneGas, 28 May 2009 - 06:04 AM.