Posted 20 October 2011 - 05:06 PM
Form of Vitamin E I suggest:
D-alpha-toccopheryl succinate.
This form has been shown to cause cell death in cultered cancer cells at non-toxic concentrations while other forms of vitamin E failed. (thanks Sven!)
Prasad KN, Kumar B, Yan XD, Hanson AJ, and Cole WC. Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. J Am Coll Nutr, 2003, 22(2): 108-117.
Wang XF, Xie Y, Wang HG, Zhang Y, Duan XC, and Lu ZJ. Α-tocopheryl succinate induces apoptosis in erbB2-expressing breast cancer cell via NF-κB pathway. Acta Pharmacol Sin, 2010, 31(12): 1604-1610.
Gu X, Song X, Dong Y, Cai H, Walters E, Zhang R, Pang X, Xie T, Guo Y, Sridhar R, and Califano JA. Vitamin E succinate induces ceramide-mediated apoptosis in head and neck squamous cell carcinoma in vitro and vivo. Clin Cancer Res, 2008, 14(6): 1840-1848.
Shiau CW, Huang JW, Wang DS, Weng JR, Yang CC, Lin CH, Li C, and Chen CS. α-tocopheryl succinate induces apoptosis in prostate cancer cells through inhibition of Bcl-xL/Bcl-2 function. J Biol Chem, 2006, 281(17): 11819-11825.
Swettenham E, Witting PK, Salvatore BA, and Neuzil J. Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system? J Neurochem, 2005, 94(5): 1448-1456.