Does yone know anything about an announcement from the NIH on the effects of resveratrol on the heart coming in a few days?
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Posted 20 February 2010 - 04:07 AM
Posted 20 February 2010 - 04:20 AM
Am J Hypertens. 2010 Feb;23(2):192-6. Epub 2009 Nov 26.
Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure.
Thandapilly SJ, Wojciechowski P, Behbahani J, Louis XL, Yu L, Juric D, Kopilas MA, Anderson HD, Netticadan T.
Heart Failure Research Laboratory, Canadian Centre for Agri-Food Research in Health and Medicine, Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada.
Comment in:
* Am J Hypertens. 2010 Feb;23(2):115.
BACKGROUND: Cardiac hypertrophy is a compensatory enlargement of the heart in response to stress such as hypertension. It is beneficial in reducing stress placed on the heart. However, when the stress is of a chronic nature, it becomes pathological and leads to cardiac dysfunction and heart failure. Current treatments for hypertension and heart failure have proven beneficial but are not highly specific and associated with side effects. Accordingly, there is an important need for alternative strategies to provide safe and effective treatment. METHODS: Ten-week-old male spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats were treated with resveratrol (2.5 mg/kg/day) for a period of 10 weeks. Systolic blood pressure, and cardiac structure and function were measured in all groups at different time points of resveratrol treatment. Oxidative stress was also determined in all groups after 10 weeks of resveratrol treatment. RESULTS: SHRs were characterized with high blood pressure and concentric hypertrophy from 15 weeks of age. Cardiac functional abnormalities were also evident in SHR from 15 weeks onwards. Resveratrol treatment significantly prevented the development of concentric hypertrophy, and systolic and diastolic dysfunction in SHR without lowering blood pressure. Resveratrol also significantly reduced the oxidative stress levels of cardiac tissue in SHR. CONCLUSIONS: Resveratrol treatment was beneficial in preventing the development of concentric hypertrophy and cardiac dysfunction in SHR. The cardioprotective effect of resveratrol in SHR may be partially mediated by a reduction in oxidative stress. Thus, resveratrol may have potential in preventing cardiac impairment in patients with essential hypertension.
PMID: 19942861
Posted 20 February 2010 - 04:47 AM
Edited by cider, 20 February 2010 - 04:49 AM.
Posted 20 February 2010 - 05:31 AM
Sure looks like a contender... but then again, one of the dates is Nov 2009. Wouldn't that announcement have come out weeks ago?
Posted 20 February 2010 - 06:18 AM
thanks for the heads up cider. where did you hear of this pending announcement?
Posted 20 February 2010 - 04:52 PM
thanks for the heads up cider. where did you hear of this pending announcement?
A friend emailed it. He just added that he heard it from a guy at a gym who said he heard it on a health podcast. More indirect than I thought. He was specific though: NIH announcement Feb 25th on resveratrol and the heart. Maybe they completed a study or are announcing a survey of studies. No idea.
Posted 20 February 2010 - 05:38 PM
Posted 20 February 2010 - 08:28 PM
Posted 20 February 2010 - 10:34 PM
Cancer conference report, Madrid - Resveratrol amazing results in monkeys for cardioprotection and diabetes @ 480mg per day
Posted 21 February 2010 - 03:18 AM
It's very possibly the NIH rhesus monkey trial. Sinclair noted promising results from it a few months ago:
Cancer conference report, Madrid - Resveratrol amazing results in monkeys for cardioprotection and diabetes @ 480mg per day
Posted 21 February 2010 - 03:55 AM
It's very possibly the NIH rhesus monkey trial. Sinclair noted promising results from it a few months ago:
Cancer conference report, Madrid - Resveratrol amazing results in monkeys for cardioprotection and diabetes @ 480mg per day
Eason, I think you hit the nail on the head. A relatively low dose of resveratrol is going to be proven effective in cardioprotection.
Edited by cider, 21 February 2010 - 03:59 AM.
Posted 21 February 2010 - 05:57 AM
Edited by cider, 21 February 2010 - 06:07 AM.
Posted 21 February 2010 - 06:33 AM
Posted 21 February 2010 - 06:53 AM
Today, Spanish-born de Cabo is conducting resveratrol trials with rhesus monkeys, the results of which are due to be published "very soon". From his government laboratory in Baltimore he tells Wired that, so far, the latest trials -- in that well worn, scientist-beloved phrase -- "looks promising".
Posted 21 February 2010 - 09:20 AM
Today, Spanish-born de Cabo is conducting resveratrol trials with rhesus monkeys, the results of which are due to be published "very soon". From his government laboratory in Baltimore he tells Wired that, so far, the latest trials -- in that well worn, scientist-beloved phrase -- "looks promising".
Edited by cider, 21 February 2010 - 09:20 AM.
Posted 21 February 2010 - 01:24 PM
Today, Spanish-born de Cabo is conducting resveratrol trials with rhesus monkeys, the results of which are due to be published "very soon". From his government laboratory in Baltimore he tells Wired that, so far, the latest trials -- in that well worn, scientist-beloved phrase -- "looks promising".
The next sentence in that Wired article is:
However, when I ask whether evidence exists from published data to support claims that resveratrol can extend human life and inhibit diseases, including certain cancers and cardiovascular disease, he says it doesn't.
That's strange. How does de Cabo know at this point that resveratrol doen't inhibit some cancers? Maybe he meant to say "We don't know yet."
The tone of the article is also odd since it seems somewhat negative while at the same time it looks like several human studies are coming out in the first half of this year.
(To niner, I did miss the weekly dosage part. Maybe not strange if just looking at the hour after effects and wanted to make sure the resveratrol was gone so spaced it weeks apart.)
Posted 21 February 2010 - 04:09 PM
However, when I ask whether evidence exists from published data to support claims that resveratrol can extend human life and inhibit diseases, including certain cancers and cardiovascular disease, he says it doesn't.
The relevant part of the statement: whether evidence exists from published data Very few studies have been done on humans, and these involved diabetes and melas.
Edited by cider, 21 February 2010 - 04:10 PM.
Posted 22 February 2010 - 08:29 PM
Posted 22 February 2010 - 08:55 PM
Posted 23 February 2010 - 02:28 AM
I am surprised no one has brought up a trading angle. Could GSK get a bounce from the data/annoucement? GSK has come off its highs and might be due for an upswing, especially on positive news. Of course, if the data promotes the benefits of natural resv products, then maybe GSK would slide further.
Edited by cider, 23 February 2010 - 02:30 AM.
Posted 23 February 2010 - 03:32 AM
GSK is in the tank because of the Avandia problems. It's a big drug for them, and it has come out that they were aware some while ago that it increased the probability of heart attacks relative to other diabetes drugs. This could open them up to a Vioxx-like wave of lawsuits.GSK rose from 38 last summer to 42 in the end of last year and recent fell to 37/38. I would think those loses are more due to what has been going on at GSK , summerized at In the Pipeline. I assume their stock will rise if SRT 501 controlled liver/colon cancer in the study they completed almost two months ago.I am surprised no one has brought up a trading angle. Could GSK get a bounce from the data/annoucement? GSK has come off its highs and might be due for an upswing, especially on positive news. Of course, if the data promotes the benefits of natural resv products, then maybe GSK would slide further.
Posted 26 February 2010 - 01:50 AM
Posted 26 February 2010 - 02:39 AM
Was the Longev*** press release the 'big' resveratrol news that was to be announced today? Mr. Sardi I think is the one, in a podcast, that got the ball rolling on this 'big' annoucement. Today he put out numerous press releases talking about Resveratrol replacing aspirin. The study in the press release was confusing (to me) as to how it related specifically to Longe** - except that Longe*& has resveratrol in it. I think I remember reading the same sort of study years ago. Was this an old study or a new study with the same results? Maybe the press release was a CYA for wrong info in the podcast?
Posted 26 February 2010 - 03:35 AM
Vapor Annoucements. Good one. I Googled resveratrol on Google News today and that is where I found the Longe*&% press releases. Check it out. RWell this is weird. I checked the Longev* website, and Sardi hasn't put up a press release since last May. Did the press release mention the NIH?Was the Longev*** press release the 'big' resveratrol news that was to be announced today? Mr. Sardi I think is the one, in a podcast, that got the ball rolling ...
"DavidWilson" posted yesterday at Sinclair's resforum.org:
"....This blog was formed when all was seemingly good in the NCE world. Now, things have seemingly changed. Resveratrol is still king as will be announced tomorrow.
Any thoughts?"
He seems interested in the Healthy Lifespan Institute and says he takes 500mg of Biotiv** a day. ...
Edited by Michael, 01 May 2010 - 10:10 PM.
Posted 26 February 2010 - 03:40 AM
Vapor Annoucements. Good one. I Googled resveratrol on Google News today and that is where I found the Longe*&% press releases. Check it out. R
Edited by cider, 26 February 2010 - 03:43 AM.
Posted 26 February 2010 - 03:44 AM
There are other advantages that resveratrol offers. Resveratrol also thins the blood in a safer manner than aspirin. Resveratrol also reduces homocysteine, an undesirable blood protein linked with heart troubles. Resveratrol inhibits inflammation and even helps heart tissues heal following a heart attack.
Edited by maxwatt, 26 February 2010 - 03:45 AM.
Posted 26 February 2010 - 03:56 AM
There are other advantages that resveratrol offers. Resveratrol also thins the blood in a safer manner than aspirin. Resveratrol also reduces homocysteine, an undesirable blood protein linked with heart troubles. Resveratrol inhibits inflammation and even helps heart tissues heal following a heart attack.
Do you have a reference for the homocysteine reduction?
Posted 26 February 2010 - 09:27 PM
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