I beleive a few months ago a video appeared of a guy presenting he's latest life extension experiment with several substances including methylene blue, SAMe en other stuff.
He also mentioned that small experiments showed that when combining supplements the results werent any better, quite the opposite and most benefits were blunted, i dont remember any details (maybe someone can help).
Also i remember someone mentioning that LEF was doing experiments on mice with a ton of supplements togheter and that they ended up giving up because heroic combo's barely showed any positive effect (i havent seen any source for this statement so i would disregard this as truth unless someone can show a link for this claim, my first example did come from a credible source).
The professor in the first thread mentioned he tougth it was because when combining supplements the doses need to be lowered.
Point of my thread is to discuss the evidence behind or against combination of supplements and to conclude wheter its best to stick with one supplement or build up a stack.
As many ppl here build stacks (wich can be pretty heroic imo) i tought it was important to discuss this, as seen with my latest posts in deprenyl i feel that we need to discuss potential harmfull effects in detail to make sure we can get positives.