When are you obtaining Sulbutiamine?
L
onge
C
ity
Advocacy & Research for Unlimited Lifespans
Posted 30 November 2004 - 07:56 PM
Posted 30 November 2004 - 07:58 PM
Posted 30 November 2004 - 08:01 PM
Posted 30 November 2004 - 10:51 PM
When are you obtaining Sulbutiamine?
Posted 30 November 2004 - 11:02 PM
Posted 30 November 2004 - 11:24 PM
The NMDA receptor is responsible for both normal cognition]excessive[/b] NMDA receptor activity results in excessive Ca2+ neuronal influx which causes neuronal apoptosis. In regards to your question, one obtains normal cognition and avoids excitotoxicity when the level of NMDA receptor activity is not excessive. In the diagram, "over activation" is the condition under which excitotoxicity ensues.
If you should require further clarification, please feel free to ask, as I am here to help.
Posted 30 November 2004 - 11:51 PM
The NMDA receptor is responsible for both normal cognition]excessive[/b] NMDA receptor activity results in excessive Ca2+ neuronal influx which causes neuronal apoptosis. In regards to your question, one obtains normal cognition and avoids excitotoxicity when the level of NMDA receptor activity is not excessive. In the diagram, "over activation" is the condition under which excitotoxicity ensues.
If you should require further clarification, please feel free to ask, as I am here to help.
Posted 01 December 2004 - 12:22 AM
Posted 01 December 2004 - 01:13 AM
Posted 01 December 2004 - 01:22 AM
That signature is linked to another site. I did not write it, you fool! If you're that upset about it, I suggest you contact the University of Illinois at Chicago and tell the person to correct the error in the diagram.todd_lee: you have a spelling error in your signature: losses is the correct way to spell the plural form of loss.
Shut your face or say something intelligent.Wow.....finally something interesting besides "Smi2le sucks" or "nootropi is _______"
Edited by todd_lee, 01 December 2004 - 02:24 AM.
Posted 01 December 2004 - 01:39 AM
1. A partial NMDA antagonist, such as magnesium or perhaps dextromethorphan.So what do you suggest to keep your NMDA receptors from being too active?
Edited by todd_lee, 01 December 2004 - 01:55 AM.
Posted 01 December 2004 - 02:02 AM
Posted 01 December 2004 - 02:14 AM
Glutamine, maybe? Let me explain why. Excessive extracellular glutamate (not glutamine) is toxic to neurons. Glial cells, specifically, the astrocytes, have excitatory amino acid transporters on their surface which remove glutamate from the synaptic cleft. Once glutamate is inside the astrocyte it is converted to glutamine, which is a rather benign substance. Glutamine is then transported to the presynaptic neuron where it is used as fuel. As you can see, the rate at which astrocytes remove glutamate from the synaptic cleft influences whether the conditions for excitotoxicity occur. When one supplements with glutamine, the presynaptic neurons have an ample supply of glutamine for energy and hence the astrocytes are not required to remove glutamate from the synaptic cleft to yield glutamine at such a rapid rate. Thus, the concentration of extracellular glutamate increases and hence this may possibly excite neurons to death.Are there nootropics that might cause excitotoxicity?
Posted 01 December 2004 - 05:45 AM
1. A partial NMDA antagonist, such as magnesium or perhaps dextromethorphan.
2. Avoid substances conducive to NMDA receptor over-activation, such as glutamate (MSG) and aspartate (NutraSweet).
3. Read 'Excitotoxins: The Taste That Kills', by Russell L. Blaylock.
Posted 01 December 2004 - 07:01 AM
About 40-60% of glutamine survives the gut. This is not exactly bad compared to alot of things.
I am one who thinks that glutamine is used by the gut for a reason -- and, as mentioned, it is because is the main source of ATP for a number of processes in the intestine, most importantly reapir and nutrient uptake.
It also increases liver ATP and cell-volume which is a fed state signal.
Layne has made this a pet peeve, and he is right about much of the nonsense he is trying to combat, but he misses the big picture, IMO
Posted 01 December 2004 - 01:44 PM
1. Repeat after me...quackwatch is not a reliable source....
quackwatch is not a reliable source...
Posted 01 December 2004 - 03:44 PM
0 members, 1 guests, 0 anonymous users