I have it as well, and have devoted a substantial amount of time to try to find some kind of treatment.
Here are the compounds I've tried:
DL-methylphenidate: About 25% improvement in symptoms, I would say. Extreme anxiety with prolonged use however.
Modafinil: About 25% improvement in symptoms as well, however, it improves a completely DIFFERENT set of symptoms than methylphenidate - it mainly helps with the fogginess and fatigue, but doesn't improve attention to any significant extent.
Combining 100 mg Modafinil with 18 mg Concerta did not improve symptoms to any extent, and I am loathe to raise Modafinil-levels when taking concerta as well.
Fasoracetam: About 20% improvements in symptoms. The least effective compound so far, even though it caused novelty-effect during the first two dosings.
Lisdexamphetamine: About 35% improvement in symptoms. Best so far, however - this may actually mainly be to what I call the "novelty-effect", every time I have had a break from dopaminergic drugs and then test a new one, this phenomenon occurs - I experience dramatically improved mood and productivity. I've experienced it at 30 mg, 40 mg, 50 mg and 60 mg's of Vyvanse. As you can see, there's a pattern here... What I'm experiencing is most likely not truly treatment of symptoms, but euphoria, which doesn't actually treat the symptoms - it just masks them.
Bupropion: 300 mg of Wellbutrin does very little, I would say it improves maybe 15% of the symptoms. The cholinergic side-effects also seem to be longer-lasting for me than the majority, and the rage-inducing effect is certainly not appealing. (seriously, I've never been so continously foul-mooded as during initial bupropion treatment). I'm actually on it right now, and the mood-effect have planed out, but the cholinergic fogginess and memory-problems are still there! Jesus...
Now remains trying Guanfacine (Intuniv) and Atomoxetine (strattera) - these two have been theorized by Dr. Russell Barkley to be more effective against SCT. They are of course the least dopaminergic as well.
Regarding unofficial treatments, I'm gravitating towards a few experimental compounds.
Metadoxine - Currently undergoing trials by an Israeli company called Alcobra. Phase III have sadly shown a very limited effect... it's one of the first studies to mention SCT and specifically aiming at the ADHD-PI crowd of patients though. Only a very select few patients had any improvements from Metadoxine - hopefully I'm one of them.
Pyritinol - A stereo-fuzion of two Vitamin B6-molecules, the fusion actually allows them to cross the blood-brain barrier and become psychoactive. I found reports from the early 2000's from ADHD-PI-ers who reported very much so improved symptoms while ingesting this drug. Apparently used to treat certain forms of cognitive decline and brain-damage in some European countries. What's especially interesting about this one, is that Vitamin B6 is actually half the components of Metadoxine! It's composed of a fusion of Pyridoxine (b6) and L-PGA, an amino-acid. Could the problem with MDX be that Alcobra can't see the forest because of all the threes?? Is it merely the Pyridoxine-part that improves symptoms? If so, Pyritinol might be more effective than Metadoxine.
AV-101 (4-CI-KYN) – kynurenic acid prodrug, potent selective nmda-antagonist. I have a hypothesis that ADHD and Schizophrenia exist on a completely separated axis - and in the middle are neurotypicals. I base this one the Kynurenic Acid Hypothesis of Schizophrenia, which combines the dopaminergic and Glutamatergic theories regarding the pathology of schizo. High KYNA and high dopamine have been reported among Schizo's, low KYNA and low dopaminerg activity have been reported among ADHD-ers. Many stimulants also trigger psychosis in Schizos, while they help ADHD-ers. The connection to me is CLEAR! KYNA is the bodies own exogenous NMDA-antagonist (and as you know, such compounds have been used in models of schizo, as they trigger hallucinations and cognitive blunting at certain doses) and Memantine is another compound which have reportedly been helpful in a subset of ADHD. AV-101 is an experimental anti-depressant which shows pro-cognitive and neuroprotective effects. Some theorize that it may succeed at blocking Glutamate excitotoxicity where Memantine failed - and with substantially less side-effects.
Alas... all of my research was based in me having ADHD, that doesn't appear to be correct... there's no telling if KYNA and NMDA-antagonism would help with SCT symptoms.
Now then... how the H*LL do I get a hold of a sample of Pyritinol?! Buying a whole bucket from Ceretropic is possible, but if it doesn't work, I will have paid quite a bit of money for a useless compound...
Anyone got any samples lying around?