Hows Your memory and cognition ?
How sensitive are You to stress and anxiety ?
I have some similair issues but accompanied with severe mood depressions.
Emotionality, mood and memory + cognition cycle sometimes through the day.
I assume (currently..sigh) for me a de-regulation of Glucocorticoid and/or Mineralocorticoid levels.
If this perhaps does affects You, then try Propolis(increases the expression of GR receptors) or Dan shen aka Salvia Miltiorrhiza
Both are bloodthinners especially Dan Shen.
So take break for 1 week before and after in regards of bloodthinners like e.g. Aspirine, Fishoil or Tumeric.
I will try morus alba bark in the next days and post it here, if You are interrested.
Here are some links for my assumption.
http://houseofmind.t...asing-factor-on
http://www.psycholog...blic-enemy-no-1
http://bipolar.about...gl_cortisol.htm
Glucocorticoid modulation of dopamine mediated effects on hypothalamic atrial natriuretic factor neurons.
http://www.ncbi.nlm....pubmed/10889539
According to them, Corticosterone lowers Dopamine and Serotonine in the Reward and motivation areas.
But increases Dopamine outflow when administered with Drugs e.g. Morphine, Ritalin, Cocaine & etc. !?
http://www.ncbi.nlm....icles/PMC22744/
Juvenile Administration of Methylphenidate Attenuates Adult Hippocampal Neurogenesis
http://psy.fsu.edu/~...idate paper.pdf
Thus probably the Anhedonia, but of course not for sure.
Furthermore lets say this is the case, what is responsible for this ?
Well perhaps: an underfunction of the hippocampus, as said lack of GR for the negative feedback loop, or a lack of MR, an alternative deregulation of the HPA axis or something different..
You see how difficult this can be -.-
Its allways good to have the luck to meet a open-minded doc. I dont have this luck..
Anyway You could probalby get an antidepressant perscribed that increase the expression of MR´s
Edited by Flex, 24 October 2014 - 08:07 PM.