http://news.berkeley...h-and-lifespan/
and
http://www.cell.com/...8674(16)30403-2
and
http://www.cell.com/...8674(16)30402-0
... these provide some clue on one thing that Calico is after ...
“Based on what we see in worms, boosting these enzymes could reprogram your metabolism to create better health, with a possible side effect of altering lifespan.”