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[alc]

"

The design of cancer-targeting particles with precisely tuned physicochemical properties may

enhance the delivery of therapeutics and access to pharmacological targets.

However, a molecular-level understanding of the interactions driving the fate of nanomedicine

in biological systems remains elusive.

 

Here, we show that ultrasmall (<10 nm in diameter) poly(ethylene glycol)-coated silica nanoparticles,

functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis

in starved cancer cells and cancer-bearing mice.

 

Tumour xenografts in mice intravenously injected with nanoparticles

using a high-dose multiple injection scheme exhibit reduced growth or regression, in a manner that is reversed

by the pharmacological inhibitor of ferroptosis, liproxstatin-1. These data demonstrate that ferroptosis can be

targeted by ultrasmall silica nanoparticles and may have therapeutic potential.

 

"

 

http://www.nature.co...o.2016.164.html