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  • Submitted: Jun 09 2017 08:32 AM
  • Views: 2068

Mithocondrial function

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melatonin coq10 vitamin c glutathione (reduced) magnesium turmeric


This is my bedtime stack to treat my mitochondrial dysfunction due to a genetic condition. After years trying to increase my ATP output, I find that I get better results by minimizing the systemic effects of the decreased ATP production.


  • It is important to take this at bedtime. I have tried the very same stack (minus melatonin) in the morning, but it does work not for me.
  • For best results, titrate the melatonin dosage. Start with 1mg and increase it by 1mg every 2-3 days until you wake up groggy. At this point, return to the last "working" dosage.
  • Note that you may need to adjust the melatonin dosage based on workout/non-workout days. I find that I need 1/3 of the dosage (1mg vs3mg) in non-workout days.
  • Melatonin + CoQ10 + Vitamin C + Turmeric is the basic stack. In my case, Glutathione and Magnesium give only marginal benefits.
  • I use Meriva for Turmeric. If you take plain old turmeric, you may need to increase the dosage significantly (and add some piperine to improve bio-availability)

This basic stack has improved my quality of life significantly. In retrospect, I find it funny all the crazy things I have tried over the years. A partial list:
  • C60 (a couple of months; no noticeable difference)
  • Methylene blue (I still remember the dizziness I got from this)
  • Low-dose DNP. I still see great potential in uncoupling the electron transport chain to treat my condition, but this one is pretty dangerous (very narrow therapeutic index)
  • Low-dose Modafinil. Great to maintain my energy levels, but at the end, it is a crash and burn for me.
  • NADH. Great for immediate energy, but it builds tolerance pretty fast. Still take it, maybe once a month.
  • All types of adaptogens (Rhodiola, Gingseng, etc). They somehow work, but not like this stack

Ingredient Dosage Frequency Administration
Melatonin 1-10 mg Daily before bedtime
CoQ10 100 mg Daily before bedtime
Vitamin C 2-3 gram Daily before bedtime
Glutathione (Reduced) 500 mg Daily before bedtime
Magnesium 200 mg Daily before bedtime
Turmeric 500 mg Daily before bedtime