ImmInst Active Topics Last Updated: 21 August 2025 - 02:30 AM

https://www.metabolismjournal.com/article/S0026-0495(25)00128-3/fulltext

https://www.sciencealert.com/aging-can-spread-through-your-body-via-a-single-protein-study-finds

Take note of the name: ReHMGB1. A new study pinpoints this protein as being able to spread the wear and tear that comes with time as it quietly travels through the bloodstream. This adds significantly to our understanding of aging.

Short for reduced high mobility group box 1, ReHMGB1 triggers senescence in cells, permanently disabling them. It doesn't just do this locally; it can send damaging signals throughout the body, particularly in response to injuries or disease.

"This study reveals that aging signals are not confined to individual cells but can be systemically transmitted via the blood, with ReHMGB1 acting as a key driver," says Korea University biomedical engineer Ok Hee Jeon.

The researchers were able to identify ReHMGB1 as a critical messenger passing on the senescence signal by analyzing different types of human cells grown in the lab and conducting a variety of tests on mice.

When ReHMGB1 transmission was blocked in mice with muscle injuries, muscle regeneration happened more quickly, while the animals showed improved physical performance, fewer signs of cellular aging, and reduced systemic inflammation.

"By blocking this pathway, we were able to restore tissue regenerative capacity, suggesting a promising strategy to treat aging-related diseases," says Jeon.

This process is only one contributor to aging out of many, but the signals that ReHMGB1 spreads are particularly important in terms of our bodies becoming dysfunctional over time and less able to carry out repairs.

Hi, this seems like a great community. 

Also I just read this in the about section:

> After your first topic, you can start posting elsewhere (there was a reason why you signed up right? It is surprising how many people don't go beyond their introductory post.) 

It's not surprising to me at all. Most people are lurkers in general, and posting isn't the reason they'll sign up (sorry if that was sarcasm and I missed it)

 

Hello,

Long story short, an experience I once had lead to a long path of self discovery, meditation/mindfulness, shifts in perception, deep insights and introspection, elevation in mood and bettering my physical and mental health. It began with with an experience of peace that I had no recollection of experiencing before. This sense of peace lasted for months. It was one in which all previous methods of pleasure seeking and avoidance of pain were no longer of importance to me and any time my mind attempted its former behaviors, I would notice and drop it right away. From time to time I would also experience the present moment without any thoughts or perceptions about what was in front of me. I experienced "beneficial" behavioral changes, elevated moods, etc. and my baseline for happiness seemed to be higher on average. I changed my diet to one higher in protein, got into supplements like goji berry, astragalus, functional mushrooms, CDP Choline, noopept, multivitamins, omega-3, etc. I also experienced greater mental clarity and memory on average. However, somewhere along the way I ended up undoing a lot of my "hard work" with kratom liquid extracts for back pain. I am now seeking to get back on track and change my lifestyle for the better. I realize I do have to get back to a healthy baseline, do adequate research and testing responsibly. I also realize that internally generated motivation and discipline play a huge role in this and pretty much anything else for that matter. However, at the moment I  am primarily looking into natural supplements for acutely boosting mood and potentially any others for increasing resilience to stress so I may get things going. I'm also aware it's up to me to not become dependent on a supplement for things that are my responsibility. If anyone has any suggestions, I'm all ears! I do have a high tolerance to caffeine and a "history of adhd" as well. I'm not sure if they'll be of any use but I have attached a few png's related to my genetics/health. Thank you in advance! 

Trying to find a legit source to purchase a good brand of Alpha Lipoic Acid (Thioctic Acid) from EU

Concentration requested: at least 600mg Thioctic Acid / vial

I am interested in quality, not cheap products.

Opinions?

trying to download someone's cronometer report but get an error, so seeing if this let's me do it.

I take Life-Extension Two-Per-Day multivitamin again, it feels superior to other multis, I particularly like the methylated B-vitamins. I notice better energy and mental clarity from it.

However, there's some corcern that the big amount of vitamin B6 could be problematic as there's speculation high amount of B6 may cause neuropathy?

Should I be concerned with this as there appears to be two forms of B6 in this multi:

I could of course only take one capsule per day so it would be 37,5 mg of B6.

This is an image from a poster I am presenting in September in Manchester, UK

The link to the text of the poster is below.

https://citrate.science/2025poster/poster2025.html

Peter Diamandis, Ray Kurzweil, Marc Adreessen, Elon Musk, and many other outrageously wealthy entrepreneurs, have been selling the idea of technological progress and a world of abundance for a couple of decades now. They keep claiming year after year that everything is going to be free or nearly so.

The reality is exactly the opposite, from the perspective of material wealth in the traditional sense - such as "the American Dream".

There are many examples that I will list in this thread, but I will start out with one obvious example: Air Travel.

Your typical middle and lower class person cannot fly very often because it keeps getting more and more expensive and less reliable every year. For those who fly commercial, it is about to get worse. Not only will you be paying more for a flight in the future, you will be even more cramped and uncomfortable than before.

There have been innumerable advancements in materials, engine design, efficiency, etc... over the last couple of decades but air travel has become more expensive and miserable for the general flying public. You don't even get a complimentary snack or beverage on some flights. You have to pay more and more for your luggage.

In a world of "abundance", we would all be flying in large comfortable/reclining seats, with complimentary food, at an easily affordable price. (business class amenities at a commercial class price)

There is no sign that air travel will get any more "abundant" anytime soon.

Aging Spreads Through The Body Like An Infection, And This Protein Could Be To Blame

https://studyfinds.org/aging-contagious-protein/

From the article:

- Aging may spread through the body via a protein called HMGB1, which sends pro-aging signals between cells—depending on its chemical state.

- Only the “reduced” form of HMGB1 triggers aging, causing healthy cells to stop dividing and release inflammatory molecules.

- Injecting this protein into mice induced signs of aging, while blocking it improved healing and physical performance in older animals.

- The findings suggest new paths for anti-aging treatments, including drugs that block HMGB1 or its downstream effects.