• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

What are some CRF1 antagonists?

crf1

  • Please log in to reply
136 replies to this topic
⌛⇒ MITOMOUSE has been fully funded!

#121 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 27 February 2019 - 04:59 PM

Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. (27 mars 2018)
https://www.ncbi.nlm...pubmed/29609111
To examine whether Lmo3 in the amygdala is important for anxiety-like behavior, we locally reduced Lmo3 expression in the BLA of wild type mice using a lentiviral vector expressing a short hairpin RNA targeting the Lmo3 transcript. Mice with Lmo3 knockdown in the BLA exhibited decreased anxiety-like behavior relative to control mice. These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression. This study is the first to support a role for Lmo3 in anxiety-like behavior.
 

 

Go figure I have a mutation in this too together with CRHR1, CRHR1-IT1 and MGC57346-CRHR1, I wonder what else controls CRHR1. ... and what decreases LMO3? Valproic acid.

 

https://www.selfdeco...o-decrease-gene



#122 Caravaggio

  • Guest
  • 71 posts
  • 8
  • Location:Germany
  • NO

Posted 28 February 2019 - 03:40 PM

Check your plasma ammonia and urinary orotic acid.

 

Quote from a German article about urea cycle disorders (translated):

Ammonia increases the transport of tryptophan via the blood-liquor barrier, which leads to an increased production and liberation of serotonin - a tryptophan restriction has proven favorable in patients with constat moderate hyperammonemia.

Hoffmann, Georg F. et al.: 2004
Referenz-Reihe Neurologie: Klinische Neurologie: Stoffwechselerkrankungen in der Neurologie

 

Without diagnosis you could try to take sodium benzoate, it reduces ammonia in an alternative pathway.


  • Pointless, Timewasting x 1

sponsored ad

  • Advert
Click HERE to rent this MEDICINES advertising spot to support LongeCity (this will replace the google ad above).

#123 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 28 February 2019 - 08:36 PM

https://www.ncbi.nlm...les/PMC3423222/



⌛⇒ MITOMOUSE has been fully funded!

#124 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 28 February 2019 - 09:43 PM

Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive

https://www.ncbi.nlm...les/PMC3475726/

 

good read on BLA

https://www.scienced...ateral-amygdala


Edited by farshad, 28 February 2019 - 09:58 PM.


#125 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 18 March 2019 - 09:20 AM

valproic acid (XR) the only thing that worked..

possibly olanzapine and lithium carbonate too

 

antipsychotic, anticonvulsant and benzo etc more likely to work since they hit a broad spectrum in the brain .



#126 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 28 March 2019 - 03:28 PM

crhr1 makes youre more emotional

https://www.ncbi.nlm...les/PMC3297975/

 

olanzapine (20-60mg) + valproate(2500mg-3k) + lithium carbonate (1200-2kmg) (memantine / tianeptine etc family/progesterone oil)



#127 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 13 April 2019 - 01:14 AM

either too much CRHR1 mutation in the hippocampus

or somewhere in the amygdala too much CRHR by the gene LMO3 in the basal amygdala

or..something with these two CRHR1-IT1 (CRHR1 intronic transcript 1) & MGC57346-CRHR1 etc


Edited by farshad, 13 April 2019 - 01:14 AM.


#128 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 11 May 2019 - 03:12 AM

(EXCESS CRHR1 AMYGDALA-HIPPOCAMPUS)
 
With an acoustic stimulus, for example, the circulation runs from the ears into the limbic system, which is located between the cerebral cortex and the brain stem.
There, in the amygdala, known as the almond core, anxiety and fear are activated in tiny fractions of a second by the stimulus of unconscious and imperceptible, fast as light flash-thoughts.The almond core, consisting of a small almond-shaped accumulation of neurons, has the characteristic and ability to put the entire organism of the human being into a highly sensitive alert-state and to cause a tension of anxiety or fear. The almond core cooperates with another factor of the nearby brain centre, namely the hippocampus, in which memories, living-experiences, situations and experiences are stored like in an archive. These are with the speed of light compared with the current threat or actually with what is regarded as an acute threat.. However, the whole process is not consciously perceived by the human being, because the conscious realisation of the anxiety or the fear only manifests itself once hormonal signals emanating from the almond core trigger the anxiety reaction or fear reaction like a torrent.
 Put in different words, the following happens: 
 The almond core sends the instruction i.e. impulse to the hypothalamus to release the corticotropin-releasing hormone.
This hormone, called CRH for short, causes the stimulation of the pituitary gland as well as the adrenal glands, through which they otherwise release adrenaline as well as noradrenaline and cortisol. But these are not the only processes, because there are several other hormonal factors at play during the whole exercise, although it would go too far to explain them.
But what ultimately results from everything is that the gastric blood vessels constrict, and the digestive processes cease, the heart begins to race, whereby the blood circulation is stimulated.
In addition, a bristling up of the hair takes place; the blood pressure rises, which increases alertness and readiness for action.
The breathing becomes faster, whereby the body can act better, because it gets more oxygen.
 Anxiety sweat, and sweaty hands are further consequences, because the blood flow to the skin is reduced in order to supply the muscles as well as the arms and legs with more blood. The liver provides a high plus in energy by ensuring that more sugar gets into the blood. Long term of this will cause the body to break down. Study request: Take 10 rats with normal CRHR1 in the hippocampus and amygdala and 2 rats with EXCESS or perhaps low levels, this will cause the ones with abnormals levels great deal of stress... BUT , take 10 rats with normal CRHR1 and 10 other rats with high CRHR1 and have them live together, in my theory nothing will happen because it is a social structure thing and there will be other rats with this excess CRHR1. Too little CRHR1 cant overcome fear via the PFC.too much CRHR1 = BAD. Because most people in society have normal levels so you'd have to have normal levels also to fit in for lack of better words. And the human body works best in a balanced way.

Edited by farshad, 11 May 2019 - 03:18 AM.


#129 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 13 May 2019 - 09:40 PM

https://en.wikipedia...Allostatic_load

 

Allostatic load is "the wear and tear on the body" which accumulates as an individual is exposed to repeated or chronic stress. The term was coined by McEwen and Stellar in 1993. It represents the physiological consequences of chronic exposure to fluctuating or heightened neural or neuroendocrineresponse which results from repeated or prolonged chronic stress.

 

https://en.wikipedia...i/Myxedema_coma

 

https://en.wikipedia...i/Levothyroxine

https://en.wikipedia...riiodothyronine


Edited by farshad, 13 May 2019 - 09:40 PM.

  • Enjoying the show x 1

⌛⇒ MITOMOUSE has been fully funded!

#130 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 09 June 2019 - 12:37 PM

amygdala, locus coeruleus  (not issue) and hippocampus. Within the hippocampus, the CRHR1s are most abundant, residing mainly on the pyramidal cells of CA1 and CA3. Chronic activation of CRHR1s by CRH induced by early life stress has been shown to underlie memory deficits and learning impairments and anxiety in adulthood.

 

In CRF1 knockout mice, and mice treated with a CRF1 antagonist, there is a decrease in anxious behavior and a blunted stress response, suggesting that CRF1 mechanisms are anxiogenic.[8][12] However, the effect of CRF1appears to be regionally specific and cell-type specific, likely due to the wide variety of cascades and signaling pathways activated by the binding of CRF or CRF-agonists.[12] In the central nervous system, CRF1 activation mediates fear learning and consolidationin the extended amygdala, stress-related modulation of memory formation in the hippocampus, and brainstem regulation of arousal.[12]


Edited by farshad, 09 June 2019 - 12:51 PM.


#131 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 10 June 2019 - 10:51 AM

crhr1 activates ketogenesis


  • Enjoying the show x 1

#132 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 12 June 2019 - 09:07 PM

 

Antidepressant-Like Effects of Shuyusan in Rats Exposed to Chronic Stress: Effects on Hypothalamic-Pituitary-Adrenal Function

Results from the present study demonstrated that Shuyusan could decrease the serum contents of CRH, ACTH, and CORT. It also could increase the expression of hippocampus GR receptor in the rat model of depression. Our results suggested that the mechanisms of action of Shuyusan were due to decreasing the serum contents level of CRH, ACTH, and CORT and increasing the expression of hippocampus GR receptor. Fluoxetine is selective serotonin reuptake inhibitors’ (SSRIs) medications, it could increase the levels of NE, 5-HT, and DA in the brain of rat and was related to downregulation of 5-HT receptor, but not decreased the serum contents level of CRH, ACTH, and CORT and increased the expression of hippocampus GR receptor.

http://www.hindawi.c...am/2012/940846/

Tables showing the reduction of CRH ACTH CORT and mRNA

http://www.hindawi.c...12/940846/fig4/

http://www.hindawi.c...12/940846/fig5/

Ingredients of Shu-Yu-San:  

Albiziae Flos, Acori Tatarinowii Rhizoma, Bupleuri Radix, Curcumae Radix, Gardeniae Fructus, Menthae Herba, Polygalae Radix, Poria, and Ziziphi Spinosae Semen.

http://www.hindawi.c...12/930908/tab1/

 



#133 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 13 June 2019 - 09:11 AM

 

 

Phosphatidylserine reduced cortisol and ACTH (which controls cortisol release) levels following a stress test in a clinical trial with 80 people. Strangely, this effect was only seen with the 400 mg dose and not higher dosages [14].

 



#134 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 13 June 2019 - 02:36 PM

Low vs high CRHR1 has a broader effect than people think.



#135 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 13 July 2019 - 05:12 PM

Drugs such as sumatriptan induce a significant decrease of ACTH, cortisol, and prolactin concentrations, both in patients with migraine and in controls (Rainero et al., 2001). Acute subcutaneous administration of sumatriptan activates the pituitary-adrenal axis: significant increases in β-endorphin and cortisol concentrations are reported across all subjects receiving sumatriptan (Facchinetti et al., 1994), and these would produce secondary effects. 



#136 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 15 September 2019 - 12:03 AM

 CRH-stimulated conductance was significantly inhibited by alpha-helical CRH-(9-41), hexamethonium, bretylium, or doxantrazole. CRH-induced enhancement of HRP flux was significantly reduced by all drugs but aminoglutethimide

 

https://www.ncbi.nlm...pubmed/10444454

 

neuroplasticity crucial for overcoming anxiety and crhr1 antagonist increases that


Edited by farshad, 15 September 2019 - 12:04 AM.


sponsored ad

  • Advert
Click HERE to rent this MEDICINES advertising spot to support LongeCity (this will replace the google ad above).

#137 farshad

  • Topic Starter
  • Guest
  • 1,024 posts
  • -39
  • Location:USA
  • NO

Posted 21 October 2019 - 09:45 AM

Antidepressant-Like Effects of Shuyusan in Rats Exposed to Chronic Stress: Effects on Hypothalamic-Pituitary-Adrenal Function

Results from the present study demonstrated that Shuyusan could decrease the serum contents of CRH, ACTH, and CORT. It also could increase the expression of hippocampus GR receptor in the rat model of depression. Our results suggested that the mechanisms of action of Shuyusan were due to decreasing the serum contents level of CRH, ACTH, and CORT and increasing the expression of hippocampus GR receptor. Fluoxetine is selective serotonin reuptake inhibitors’ (SSRIs) medications, it could increase the levels of NE, 5-HT, and DA in the brain of rat and was related to downregulation of 5-HT receptor, but not decreased the serum contents level of CRH, ACTH, and CORT and increased the expression of hippocampus GR receptor.

http://www.hindawi.c...am/2012/940846/

Tables showing the reduction of CRH ACTH CORT and mRNA

http://www.hindawi.c...12/940846/fig4/

http://www.hindawi.c...12/940846/fig5/

Ingredients of Shu-Yu-San:  

Albiziae Flos, Acori Tatarinowii Rhizoma, Bupleuri Radix, Curcumae Radix, Gardeniae Fructus, Menthae Herba, Polygalae Radix, Poria, and Ziziphi Spinosae Semen.

http://www.hindawi.c...12/930908/tab1/







Also tagged with one or more of these keywords: crf1

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users