(EXCESS CRHR1 AMYGDALA-HIPPOCAMPUS)
With an acoustic stimulus, for example, the circulation runs from the ears into the limbic system, which is located between the cerebral cortex and the brain stem.
There, in the amygdala, known as the almond core, anxiety and fear are activated in tiny fractions of a second by the stimulus of unconscious and imperceptible, fast as light flash-thoughts.The almond core, consisting of a small almond-shaped accumulation of neurons, has the characteristic and ability to put the entire organism of the human being into a highly sensitive alert-state and to cause a tension of anxiety or fear. The almond core cooperates with another factor of the nearby brain centre, namely the hippocampus, in which memories, living-experiences, situations and experiences are stored like in an archive. These are with the speed of light compared with the current threat or actually with what is regarded as an acute threat.. However, the whole process is not consciously perceived by the human being, because the conscious realisation of the anxiety or the fear only manifests itself once hormonal signals emanating from the almond core trigger the anxiety reaction or fear reaction like a torrent.
Put in different words, the following happens:
The almond core sends the instruction i.e. impulse to the hypothalamus to release the corticotropin-releasing hormone.
This hormone, called CRH for short, causes the stimulation of the pituitary gland as well as the adrenal glands, through which they otherwise release adrenaline as well as noradrenaline and cortisol. But these are not the only processes, because there are several other hormonal factors at play during the whole exercise, although it would go too far to explain them.
But what ultimately results from everything is that the gastric blood vessels constrict, and the digestive processes cease, the heart begins to race, whereby the blood circulation is stimulated.
In addition, a bristling up of the hair takes place; the blood pressure rises, which increases alertness and readiness for action.
The breathing becomes faster, whereby the body can act better, because it gets more oxygen.
Anxiety sweat, and sweaty hands are further consequences, because the blood flow to the skin is reduced in order to supply the muscles as well as the arms and legs with more blood. The liver provides a high plus in energy by ensuring that more sugar gets into the blood. Long term of this will cause the body to break down. Study request: Take 10 rats with normal CRHR1 in the hippocampus and amygdala and 2 rats with EXCESS or perhaps low levels, this will cause the ones with abnormals levels great deal of stress... BUT , take 10 rats with normal CRHR1 and 10 other rats with high CRHR1 and have them live together, in my theory nothing will happen because it is a social structure thing and there will be other rats with this excess CRHR1. Too little CRHR1 cant overcome fear via the PFC.too much CRHR1 = BAD. Because most people in society have normal levels so you'd have to have normal levels also to fit in for lack of better words. And the human body works best in a balanced way.
Edited by farshad, 11 May 2019 - 03:18 AM.
