I don’t see how these studies are more significant than NR studies, especially the clearance of plaques in the mice brain. NR study also extended life span in mice when started late in life. Human studies are ultimately the answer to their effectiveness. Mice studies are just prove of concept.
The Colorado study picked a bunch of very healthy people with perfect cholesterol and glucose. So there was no improvement their. But luckily some of these people have blood pressure between 120 and 139, NR improves blood pressure on these people. The Elysium trial used basis which contains Pterostilbene. Pterostilbene increases cholesterol. So it cancels out the good effect of NR.
Clearance of plaques is good, but not a dramatic anti-aging example imo. I do agree, the extension in lifespan that was kind of implied in that one study with NR was encouraging, but there is no detail at all on that.
Are there any examples of NR increasing endurance almost 100%? Promoting NEW blood vessel growth in very old mice? Making muscle in old mice look identical to young mice?
Below are some quotes from the 3 studies I mentioned that show the most dramatic anti-aging effects, plus one other.
Can you point to similar with NR? Again, I'm not talking about improving symptoms in diseased or unhealthy animals, but reversing some aspects of aging in healthy animals.
After 6 days of NMN, 22 month old mice had the muscle capacity, endurance and metabolism of 6 month old mice (2013 Sinclair)
NMN effectively mitigates age-associated physiological decline in mice (2016 Mills)
“NAD+ and SIRT1 levels were HIGHER in OLD Mice than in YOUNG Mice that did not receive NMN.” (Hao, 2017)
“The old mice became as fit and strong as young mice” (Sinclair, 2018)
Edited by able, 28 May 2018 - 03:13 AM.