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Resveratrol inhibit Sirt1 and promote apoptosis


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#1 MikeDC

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Posted 09 June 2018 - 01:15 PM

Is this study finally reveal the true nature of Resveratrol?
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#2 John250

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Posted 09 June 2018 - 08:07 PM

What does this mean?

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#3 Oakman

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Posted 09 June 2018 - 09:39 PM

What does this mean?


I think the takeaway is that it doesn't mean much, except to dermal fibroblasts in a test tube bath with resveratrol at varying concentrations.


It seems research may point to resveratrol doing good things for people (in this case women) with abnormal metabolisms or some diseases, but little for healthy people, at least metabolically. Your personal results may vary, and there are other contradictory results from other studies.


"The present study provides a comprehensive evaluation of the use of resveratrol in nonobese women with normal glucose tolerance. Our findings demonstrate that 12 weeks of resveratrol supplementation (75 mg/day) increased plasma total resveratrol and total dihydro resveratrol concentrations but did not alter liver, skeletal muscle, or adipose tissue insulin sensitivity and did not have any effects on other key metabolic variables, such as body composition, plasma lipids, plasma markers of inflammation, or resting metabolic rate. Furthermore, resveratrol supplementation did not affect its major putative molecular targets in either adipose tissue or skeletal muscle, including SIRT1NAMPTPPARGC1A, and UCP3 expression, AMPK phosphorylation, and biological pathways linked to mitochondrial function or inflammation. These data show that resveratrol supplementation (equivalent to the amount of resveratrol ingested by consuming ∼8 liters of red wine per day [Stark et al., 2011]) in nonobese women with normal glucose tolerance does not affect cellular signaling or result in metabolic benefits."

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#4 recon

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Posted 11 June 2018 - 05:30 AM

This is concerning though.

One of us should send that to Dr Sinclair. Haha.
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#5 QuestforLife

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Posted 11 June 2018 - 08:02 AM

And yet 5uM of resveratrol can rescue senescent (or near senescent) fibroblast cells via telomere elongation:




And 10-50uM does something similar in endothelial progenitor cells:




And it looks like the mechanism is an adjustment of RNA splicing factors, probably related to the shape of the resveratrol molecule, not SIRT (see first paper).


The concentrations in the paper Mike quoted were 25-100uM, and proliferative arrest was greatest at 72hours.


It would be almost impossible to get a level of 25uM of resveratrol in the blood, let alone keep it there for 72 hours, see:




For reference, the highest resveratrol dose group at 5g, if you do the conversion from ng/mL, got about 2.4uM in the blood.


So relax people.




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