6 replies to this topic

[floweryriddle]

There’s not much discussion on Memantine out there. I have a little experience thread particular with Methylphenidate (https://www.longecit...away-with-time/) but thought a more general discussion might be better. 

 

Discussions on reddit usually just state "better focus", "more energy", "better memory recall" which is all a little too broad (especially the last one, seems a bit odd given how Memantine works).

 

I’ve been experimenting with Memantine over the past months on and off primarily to keep tolerance to stimulants down but still don’t really know what to make of it. 

 

Some things I noticed (very subjective) 

 

- almost no effects on cognition besides having a harder time to remember things in the beginning

- other substances feel amplified. Phenibut feels stronger (low dosages feel like high, high dosages give me more subjective euphoria), Methylphenidate on Memantine feels like my head is going to explode. 

- Memantine in combination with strattera gives me effects that a high dosage is strattera would, mainly reducing adhd quirks like impulsiveness. (Both act as NMDA antagonists, if this could mean anything)

- I often get drowsiness during the day when taking in the morning. Not when in the evening

 

All of these things are very subtle and very subjective. I have no idea if I'm just imagining things or if this is actually what's happening. 

I want to do a lot more back and forth tests, but the the dissociative effects when starting a Memantine run are always pretty strong and I feel like an idiot. This makes this a little difficult to quickly try and confirm interactions. 

 

There's also this study https://www.ncbi.nlm...pubmed/21860092, stating

 

 

 

Alternatively, memantine could induce a long-lasting effect on memory formation through persistent effects on other receptor types, potentially in a manner similar to the persistent impairing effects of isoflurane on spatial fear memory [28]. Interestingly, the persistent memory impairing effects of isoflurane depend on 5GABA(A) receptor subunit activation [28], and memantine is known to affect GABA(A) receptor neurotransmission in mice [13]. Finally, the observed release of dopamine in the prefrontal cortex following memantine administration [11, 12] could be of considerable importance, since dopamine release in this area of the brain is already linked to cognitive flexibility in both experimental animals, as well as humans [29]. A deeper investigation of memantine’s novel and unusual detrimental effects on cognitive flexibility may shed light on new treatments for AD.

 

 

Anyone here experimented with Memantine in the past or is currently taking it? 

What are your experiences? 

 

[John250]

On day 3 of 5mg which is a pretty low dose but I’m going to run it for a week and then increased to 10. So far feel nothing.

[John250]

On day 3 of 5mg which is a pretty low dose but I’m going to run it for a week and then increased to 10. So far feel nothing.

Actually come to think of it, and I don’t even know if there is a scientific explanation for this, but I’ve noticed the past three days I’ve needed more and more amphetamines since starting Memantine. I figured it would’ve been the complete opposite. Maybe the stuff just takes some time to start working I sure hope so. So far the only thing I have used that lets me use about half the amount of Adderall I normally use is if I add a very low-dose Opiate. Like maybe 3-5mg oxy.

Edited by John250, 21 June 2018 - 08:00 AM.

[floweryriddle]

Thanks for chiming in!

 

Yeah, from my experience Memantine needs some time to to ramp up. Usually 1-2 weeks. Also best effects for stimulants seem to be when you start taking Memantine days before you start the stimulant so it can actually help with the tolerance. 

I also read that the most benefits happen at around 20-30mg. My own experiments were at max 20mg, but I didn't notice much difference to 5mg so I usually just stayed at 5. 

 

I am back on my Memantine break to check if things are any different, and noticed that my Methylphenidate is barely noticeable anymore. On Memantine I feel a rush every single day I take it, today I am even questioning if I took my morning dosage. Definitely interesting. 

I might start another Memantine run from Monday if things stay the same as they are today. 

 

 

 

What worries me more are the effects on memory and dissociation. Something that effects memory this strong in healthy people just doesn't sound very good to me.

Plus the study I linked above implied that there could be permanent effects (10mg/kg in mice like done in the experiment should be somewhat around 50mg for a 60kg human)

Edited by floweryriddle, 22 June 2018 - 12:45 AM.

[John250]

This morning was a little interesting. Day 4 and I only took 2.5 mg Memantine instead of the usual 5mg with my usual Vyvanse. About two hours later I was driving and as I was drinking my protein shake I noticed my hand was shaking and trembling which never happens. I didn’t feel any more alert than normal and I still feel I need the same Adderall dosage throughout the rest of the day to get my motivation but I could definitely tell I was jittery this morning for some reason.

[floweryriddle]

It's been roughly a week since I stopped Memantine. I still think my MPH feels weaker than it was before. ADHD impulsiveness seems stronger and motivation feels like it took a hit as well (as in, it's harder to start tasks, even when I'm on MPH). Again, very very subjective. Describing feelings is always a tricky thing. 

 

I read on some reddit experience threads (like this one) that it helped with motivation and procrastination in people with ADHD but I'm a little unsure what mechanisms in memantine would result in that. Did you notice any of that John250? 

Edited by floweryriddle, 26 June 2018 - 01:19 AM.

[John250]

It's been roughly a week since I stopped Memantine. I still think my MPH feels weaker than it was before. ADHD impulsiveness seems stronger and motivation feels like it took a hit as well (as in, it's harder to start tasks, even when I'm on MPH). Again, very very subjective. Describing feelings is always a tricky thing.

I read on some reddit experience threads (like this one) that it helped with motivation and procrastination in people with ADHD but I'm a little unsure what mechanisms in memantine would result in that. Did you notice any of that John250?

I’ve been on it for maybe seven or eight days now and I actually feel that it’s making me worse. I’m having way more obsessive compulsive disorder’s, cannot get any done have zero motivation, etc.