Very interested in this topic, and more importantly, what we can do to prevent such issues. As anyone who's read the reports on this combo knows, PEA + selegiline is basically the epitome of bliss, the purest form of orgasmic euphoria known to man. If we could channel that feeling all the time, sustainably and in a non harmful manner, I believe we'd have a major key to the universe for becoming limitless like Bradley Cooper.
Now, I believe much if not all of the actual neurotoxicity of amp comes from oxidative stress, so powerful antioxidants should alleviate much of the damage. PEA + MAOI is also known to be highly stressful to mitochondria so I've read that it is essential to take some mito protectors like CoQ10 (preferably a really absorbable form like CoQsol-CF), PQQ, stuff like that. I've also read that one should take SAMe with the combo but I forget why, let's research that more. Memantine should be able to slow/prevent tolerance.
The most important issue is that of any reward system damage which will likely be mediated by the opioid system, particularly kappa and mu opioid. We need to figure out how to avoid getting anhedonia from all the downstream opioid effects. I have bad anhedonia rn and it's absolute hell, I'm not sure how to protect the opioid system but this report about smoking salvia on a meth comedown makes me think that using it after PEA + MAOi could be a similarly good idea: https://www.longecit...ndpost&p=669404
Any advice or suggestions on all this would be greatly appreciated!
Edited by jacobjerondin, 20 June 2019 - 03:10 AM.
