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Afraid of dopamine hypersensitivity from low dose stimulants

amphetamines dexedrine stimulants adhd sct hypersensitivity adderall ritalin dopamine microdose

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#1 RegainBrain

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Posted 17 July 2018 - 03:41 PM


Because of my ADHD (and maybe SCT), I take stimulants.

 

There is no really continuity in my stimulants intake, sometimes I take less, sometimes more and sometimes off.

My doc gives me a lot of freedom, because I'm not that regular ADHD-guy, my condition is a little bit more complicated.

This means, I have only IR (direct release) stimulant prescriptions and not the retarded ones.

 

Because I couldn't handle the side-effects of ritalin anymore, I began to take dexedrine (pure dextroamphetamine).

First times experience: sleep. They made me tired, but that was not surprising:

I didn't took the amphetamin:ritalin-ratio seriously, so I took 5 or sometimes 10mg at once.

 

For me, who is satisfyed with only 5-7,5mg of ritalin, that was a little overdose.

 

The heavy dopamine release resulted in tiredness, lazyness and complete lost of motivation: because I'm satisfied.

 

I realised that 2,5mg is a really good fitting dosage, which should/can last ~4 hours for me.

 

TL;DR

 

Because I took these large amounts of dextroamphetamine (10-15mg/day) for some weeks, I'm now afraid that switching to 2,5mg can cause some weak hypersensitivation of the dopamin receptors.

 

Since hypersensitivation can be really long-lasting (2-3 years), I want to ask you for some experience.

 

Should I just take a big cold turkey break and then start with 2,5mg or can I just switch to it now?

 

PS: For some reason, my withdrawals are non-existent. When I'm off cold turkey, I'm energized as hell in the next 4-5 day's...also with ritalin.

 



#2 John250

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Posted 17 July 2018 - 04:38 PM

10-15mg dextroamphetamine isn’t much at all. If you taper to 2-5mg you will be fine.
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#3 giant

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Posted 22 July 2018 - 11:27 PM

Have I just found my ADHD twin?

I am the same as you with regards the medicine. 2-5 mg of Dex IR is what I need.

Methylphenidate though, either Slow release or instant release and no matter how low the dose, it turned me into a emotionless socially inept being. Worst thing was that I put up with it for 9 years before switching to Strattera (nightmare medicine although made me super organised but not much focus at all really. Just excessively tired most of the time).

After that I got switched to Dexamphetamine then 30mg Duloxetine was added to aid the anxiety disorder.





Also tagged with one or more of these keywords: amphetamines, dexedrine, stimulants, adhd, sct, hypersensitivity, adderall, ritalin, dopamine, microdose

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