6 replies to this topic

[Kaveh]

Hi guys,  

 

Just a quick disclosure before I begin: I'm a compounding pharmacist at Superpharmacy, which operates a compounding laboratory in Sydney.

 

We have been really impressed with the positive results and the safety profile of Niagen, particularly with the latest papers that were published earlier in the year. As a lot of you may know, Nicotinamide riboside still has NOT been approved in Australia by the TGA, prohibiting Australian pharmacies from supplying it to patients. Compounding pharmacists, however, are exempt from these restrictions if the medicine is considered safe and no commercial product is available in Australia. 

 

This led to us contacting Chromadex in May and have partnered with them to bring the Niagen brand of Nicotinamide riboside to Australian population. We are currently preparing it in 125mg, 250mg and 500mg capsules, and are working on an effervescent formulation which is planned to be released by October. 

 

Feel free to contact us or post your questions here and I'd be happy to oblige. 

 

Cheers

[dontwakeme]

Hi,

 

My parents are in Brisbane and might like to try some.  How would they order it from you?

 

Thanks.

[Kaveh]

Hi, 

 

They can order it through our website ( superpharmacy.com.au ) or by emailing us at pharmacist@superpharmacy.com.au

 

Although Niagen doesn't require a prescription, we must check for any drug interactions or medical conditions prior to supplying this medicine. They simply have to create an account and let us know of any medical conditions they may be suffering from and if there are no interactions we can ship it out within ONE business day. Niagen also carries no shipping and handling fees.

 

Cheers

 

 

Edited by Kaveh, 06 August 2018 - 02:47 AM.

[hd98]

Can't seem to find the 500mg capsules on your website. Is it not on sale yet?

[Kaveh]

Can't seem to find the 500mg capsules on your website. Is it not on sale yet?

 

Hi, unfortunately, TGA prohibits us from compounding strengths that have not yet been approved by a similar regulatory body without a prescription. That is because FDA has provided Niagen with GRAS Approval (Generally Recognised As Safe) only for doses below 250mg.

 

You can order Niagen 500mg capsules if you obtain a prescription from an Australian prescriber. We do know an Australian doctor (Dr Richard McMahon) who is familiar with Niagen and may provide you with a prescription. You can organise an online consultation with him by clicking on the link below: 

 

https://www.swiftdoc.com/

 

Alternatively, you can simply take 2 x 250mg capsules. 

 

Hope this has been helpful.

[Kaveh]

I also wanted to make some quick updates as well:

 

• Due to unprecedented demand, we have currently exhausted all of our Niagen stock. We have placed another order with Chromadex and are expecting the next shipment to arrive from the US by this Friday 21/9/18. Sorry for any delays you may be experiencing. 

 

• We have been contacted by many of you enquiring about possible precautions with Niagen. At this point, we are recommending all of the following patients to avoid taking Niagen until further studies are published to ensure its safety:

 

1. Diabetics:It’s been well established that Nicotinic acid (Niacin) stimulates glucose output from the liver. There is a theoretical risk that Niagen may have similar pharmacological effects so it's best to avoid use or keep monitoring your sugar levels to ensure it's not raising your blood glucose levels.
2. Cancer patients: Some tumours show increased NAMPT expression. Interventions that increase NAD+ might enhance or promote tumour development in those suffering from specific types of cancers. NAMPT is usually over-expressed in several cancer types such as colorectal, ovarian, breast, gastric, prostate, gliomas as well as B-cell lymphomas. Patients diagnosed with cancer should avoid all forms of Vitamin B3 and tryptophans, which includes Niagen.

Feel free to contact us with all your enquiries. We'll be doing our best to answer all your questions.

 

Edited by Kaveh, 14 September 2018 - 06:38 AM.

[stefan_001]

@Kaveh that is a broad statement wrt cancer. I would recommend that cancer patients discuss with their treating physician.

 

Here an interesting study wrt glioblastoma:

 

Magnetic Resonance Imaging of Tumor Growth and Leukocyte Infiltration in Brain Tumors after Stimulation of the Innate Immune System

https://prism.ucalga...dle/1880/106831

This thesis showed that niacin treatment can reduce tumor growth by stimulating monocytes.

(From another study: We found that NAMPT was highly overexpressed in glioblastoma tissue compared with healthy brain tissue)

 

Or this study in B vitamins and breast cancer:

We used a population-based cohort of 1,508 women with breast cancer to investigate possible associations of dietary intake of B vitamins before diagnosis as well as nine polymorphisms of one-carbon metabolizing genes and subsequent survival. Women newly diagnosed with a first primary breast cancer in 1996 to 1997 were followed for vital status for an average of 5.6 years. Kaplan-Meier survival and Cox proportional hazard regression analyses were used to evaluate the association between dietary intakes of B vitamins (1,479 cases), genotypes (∼1,065 cases), and all-cause as well as breast cancer–specific mortality. We found that higher dietary intake of vitamin B1 and B3 was associated with improved survival during the follow-up period (Ptrend = 0.01 and 0.04, respectively).

http://cebp.aacrjour...17/8/2109.short