8 replies to this topic

[jetmango]

After I slowly changed my lifestyle from smoking, drinking and partying (drugs in early adulthood- ecstasy, amphetamines etc) to cycling, doing yoga, weightlifting etc - adjusting my diet from sweets and crisps/chips to healthy fruit & veggies, changing from being a vegetarian to a normal meat eater [mostly poultry and lamb, sometimes beef] - and taking a lot of supplements to fix my brain (brain fog, anxiety, social anxiety etc) like amino acids, various brain nutrients, vitamins etc. L-tyrosine, L-tryptophan, DLPA, and tons of others [looking for a holy grail and fixing what can be fixed!] also eliminating addiction to pornography - I felt good but still not great. Social interactions tired me after a while. I had to take a long rest after every day filled with social interactions at my work in the office. And stress was a killer. However, I was reacting very well to nettle root. Due to its aromatase inhibiting action - I felt stronger, grounded more manly. Okay! I started to connect the dots and maybe my past unhealthy lifestyle created bad amounts of both DHT and estrogen dominance. I gave a try to Indole 3 Carbinol. And I'm on day 8 of taking it... and I can't believe it. It literally changed me into super-confident social beast, feeling energetic, but grounded. I can easily say I haven't felt that good since a decade when I was 26. Now, I am trying to understand this but I haven't found any good information if this supplement influences neurotransmitters in any way. I feel that specific DOPAMINE drive - I read that we have testosterone receptors in the brain. But... could eliminating excess toxic estrogen created such action? Of course, testing it all would be good but I cant do it currently [financial reasons] so I al left to wonder.... Also I know that if something goes up, it tends to go down - I literally feel HIGH from it. And I dont know why. Any ideas, guys? I am taking it on a 3-4 days ON and 3-4 days OFF- cycling so that I can still feel normal at times. I remember back in the years when I started taking L-Lysine I felt EUPHORIC for WEEKS. Turned out I had so much shortages of serotonin! (And I am supersensitive to everything, btw - im taking 200mg of Indole 3 carbinol now. Just once, during morning). But now I feel like I believe I should always felt... without stupid fears or anxieties. Being able to be fully myself! But somehow it feels like I was on a low dose of amphetamine or bi-polar [but on that high euphoric edge on the moment]. What do you think of it?

[John250]

I use the NOW brand for its health affects but never felt a thing from it. I didn’t know it helped with estrogen I thought that would be DIM and Calcium D-Glucarate.

Edited by John250, 22 August 2018 - 10:14 PM.

[Boopy!]

I get those days -- used to at the end of the month,   but now I get them so rarely.    But mine were naturally acquired and usually occurred when I was taking NOTHING --   so you are lucky.   Also,   keep testing it if you can.   Congrats on getting your health back!   I know exactly what you mean;  you describe that almost too much feeling so well.

[jetmango]

I literally can't figure it out. I feel fantastic but from my experience I know that nothing comes free... it's either my estrogen levels were way too high ( last time I checked my T - more than 3 years ago when I was still eating pretty unhealthy) it was 17.48 nmo/L so I guess it wasnt too bad )

or idk what. Indole 3 carbinol changes unhealthy E types to more healthy ones.

 

http://digitalnaturo...at/T271617.html

 

remember that Indole 3 carbinol is basically transformed in our bodies into DIM.. and some people react better on DIM on its own. 

 

 

[jetmango]

And a small update today on my 8th day I slowly started coming down - I didnt felt as high. Maybe due to tiredness and sleeping 2 hours less than usual, or maybe due to using up all of my neurotransmitters [and need to make new ones lol] - also I should prolly mention that I had problems with methylation in the past [and tried to correct it with SAM-e , methylation protocol [vita cure methyl supplement] ] - but I do best on single supplements like TMG .. when I take methyl donors all at once from that supplement I also feel VERY social and cheerful for a day and two and then I crash and basically feel like a pussy - like it does something with my estrogen levels. It might have some sort of connection in there, I am not sure.

 

I know that 3 indole carbinol doesnt interact with neurotransmitters but - well - maybe we dont know everything or it does... not directly but through altered estrogen / testosterone levels because the high was definitely dopaminergic...

[jetmango]

Interesting thing - after 10 days I felt like a pussy on it.... funny, eh? How is this possible? Dosage was too high? I heard that sometimes it can cause this. If the E levels were too high, it limits them down ... if they are too low - it puts them up. But it doesnt make sense. Let's say I had 120 E [made up amount just to illustrate] and healthy level is 90. So it lowered it to 80 and then assumed its too low so it put it to 120? Doesnt make sense, right?

 

So I keep looking and boom! Turns out that in some way I-3-C also boosts methylation !! And I have this faulty MTHFR gene! And every time I am taking methyl donors... read my post above!!

 

So what shall I do now? How come this is all related somehow? My voice from being deep is already sounding soft lol. It's like a switch. So I either need to lower the dose [200mg daily now] to , say, 50mg and then see ... or quit it all together because to be honest, I like my normal masculine deep voice. What's the point if this is killing it. And to be honest, I don't understand why the methylation supplements [so, aiding the methylation process] are doing that to me? 

 

 

The only difference between taking methyl supplements and I-3-C was that I felt on top of the world for 7 days AND still masculine/high libido/high T ... with methyl supplements I start feeling like a pussy after 2-3 day already. Here it wasn't noticeable until day 8. 

 

Anyone got any ideas? 

The only difference between taking methyl supplements and I-3-C was that I felt on top of the world for 7 days AND still masculine/high libido/high T ... with methyl supplements I start feeling like a pussy after 2-3 day already. Here it wasn't noticeable until day 8. 

 

Anyone got any ideas? 

[Drsherbert]

How about taking your B vits in unmethylated form? I have mthfr 6667T homozygous. Some days the methylated B’s make me feel awesome. It’s about 50/50. I just started pregnenolone at night along with LLLT, 1/8 tsp borax, vit E, zinc, mag glycinate and took some DIM this morning. I was laser focused on research till 4am with red screen on my phone. I think the pregnenolone caused it. Either way, I woke up at 7:30 with the hardest erection I’ve had since I was 19 (41 now) and It went down after I pissed in the shower. Now I’m back to rumination, low motivation and apathy again. Sleep deprivation is definitely a factor. I should mention I also have chronic adhd and anxiety which I’m medicated for.

[MankindRising]

Interesting thing - after 10 days I felt like a pussy on it.... funny, eh? How is this possible? Dosage was too high?

SHBG half-life is around a week, after that homeostasis sets in and the body turns it up a notch and compensates for the increased amount of total t thats floating around in your body.

Basically what I think happens is that you temporarily get a free testosterone boost due to estrogen being metabolized more quickly out of your system. Your body compensates by making more total testosterone, now at this point your shbg is still what it normally is and you are reaping benefits of higher total at your old shbg and thus have more free t levels. Till the body recompensates for that.

 

This is my theory, other people feel free to comment on it.

[jetmango]

it does make sense

 

however, if homeostasis kicks in so fast why doctors are recommending stuff like DIM [or beta 3 carbinol] for correcting excess estrogens, for example? 

 

if my T is somewhat lower than it should be, it shouldnt do that.

 

[I had good response with nettle root extracts in limiting aromatase - I could say that tolerance kicked in after 3-4 months, but it can be cleared by doing breaks from it]