9 replies to this topic

[ironfistx]

During the times I take these, i feel worse.  Usually I take Swanson active B which are all ideal version of them.  Except the dose is so big that sometimes I just separate the capsule and put a bit of it under my tongue and take it that way.  Once I take it I feel brain fog.  Besides that, I notice a strengthening of OCD.  I figure I need them though because I don't think I eat anything with B forms in it and  I don't eat fortified cereal or anything.  But man, I just feel off when I take them.

[KBAnthis]

The best b-vitaamin I found was garden of life. Maybe try another brand and see if you feel better.

[baccheion]

Try AOR Advanced B-Complex. B-complex formulations normally make me feel worse (malaise, fatigue, lethargy, depression, etc), but I didn't have that experience with AOR's product.

Maybe it's choline. Maybe it's riboflavin.

[Kimer Med]

Feeling worse when taking Vit B is very common. Many people are sensitive to one or more of the B's. You might try taking them individually to find out which ones.

 

As with many supplements, when your health isn't perfect, replacement often needs to happen in a layered way -- adding a little at a time of several different things, and then increasing or adding more only when you can tolerate them.

 

You may find that you need minerals first, for example, before you can comfortably handle all of the B's.

 

Some people are also very sensitive to particular brands. High-quality brands tend to be better tolerated. Others are sensitive to particular forms of the vitamins, and do fine by changing to a different type.

 

[dzidek794]

The same here. I had extremely adverse reaction to Stress B-complex. I had extremely anxiety and insomnia. Lately I tried again some b6 and again I cound't sleep at night or have been waking up always around 2-4 am which indicates liver problems? Anyway I will try to confirm that and try it again in the nearest future cause I mixed it sometimes with SAM-e so being sure that it was B6 can be misleading. 

 

[ironfistx]

Here are some more peculiar observations about b vitamins.

 

When I take cyanocob b12 I feel regular or fine.  When I take methyl b12 I feel unusual.

 

This b vitamin that is making me feel bad is all activated form.  Maybe a regular one wouldn't?

 

I read on a couple posts on this forum that activated forms have to be taken in correct amount compared to regular version.  Is this correct?  I don't grasp why that would be the case because your body converts it anyway, accurate?

 

I have taken p5p before by itself when I had tendonitis and I think I felt unusual.  Or maybe I was thinking I was taking too much (50mg) because I remember splitting them into halves and quarters.  FWIW I think I might have been low in magnesium and D at that time.

 

From what I read here, the methylation thing isn't as important as everyone makes it sound.

[John250]

Here are some more peculiar observations about b vitamins.

When I take cyanocob b12 I feel regular or fine. When I take methyl b12 I feel unusual.

This b vitamin that is making me feel bad is all activated form. Maybe a regular one wouldn't?

I read on a couple posts on this forum that activated forms have to be taken in correct amount compared to regular version. Is this correct? I don't grasp why that would be the case because your body converts it anyway, accurate?

I have taken p5p before by itself when I had tendonitis and I think I felt unusual. Or maybe I was thinking I was taking too much (50mg) because I remember splitting them into halves and quarters. FWIW I think I might have been low in magnesium and D at that time.

From what I read here, the methylation thing isn't as important as everyone makes it sound.

For my MTHFR mutations I followed the protocol from this website which for me means methylb12, regular Vitamin B6 and folic Acid are not good for me and I need adenosylcobalamin, hydroxycobalamin, P-5-P and (6s)-5-Methyltetrahydrofolate. But I’ve used all forms of each and never really noticed any positives or negatives.

https://methyl-life....st-form-of-b12/

Edited by John250, 14 September 2018 - 10:31 PM.

[Kimer Med]

Here are some more peculiar observations about b vitamins.

 

When I take cyanocob b12 I feel regular or fine.  When I take methyl b12 I feel unusual.

 

This b vitamin that is making me feel bad is all activated form.  Maybe a regular one wouldn't?

 

I read on a couple posts on this forum that activated forms have to be taken in correct amount compared to regular version.  Is this correct?  I don't grasp why that would be the case because your body converts it anyway, accurate?

 

I have taken p5p before by itself when I had tendonitis and I think I felt unusual.  Or maybe I was thinking I was taking too much (50mg) because I remember splitting them into halves and quarters.  FWIW I think I might have been low in magnesium and D at that time.

 

From what I read here, the methylation thing isn't as important as everyone makes it sound.

 

Here are the guidelines for which type of B12 to take when:

 

Methyl-B12: Ideal when oxidative stress and nitric oxide (NO) levels are fine. Best when taken with methylfolate (MTHF), although MTHF should usually be added after taking Methyl-B12 for a while.

 

Hydroxo-B12: Ideal with elevated reactive oxygen species (ROS) and elevated NO. Helps lower NO. Don't use MTHF yet.

 

Adenosyl-B12: Active form in mitochondria. Ideal with elevated Methylmalonic Acid (MMA) or SNPs in the cobalamin genes. You can use it with MTHF is NO isn't elevated.

 

Cyanocobalamin is a synthetic compound that isn't found in nature. It is converted in the body to methyl-B12 and adenosyl-B12. Although most people don't have a problem with methyl-B12 alone, there are genetic conditions that can impair the important and necessary conversion of methyl-B12 to adenosyl-B12.

 

It's also worth mentioning that FAD (from Vit B2) is a co-factor for the MTHFR enzyme, which is central to B12 and folate metabolism. Some who don't handle B12 or folate well may need more B2.

 

B6 (P5P) is a cofactor for the CBS enzyme, which leads to glutathione and detox. Some people are sensitive to B6 because it revvs-up their detox system too much. Others are sensitive to it because it diverts homocysteine away from MTR/MTRR (methionine recycling), effectively depriving them of methyl groups and their downstream uses (including creation of neurotransmitters). If the cause is the latter, supplementation with Magnesium may help (Mg is required for the conversion of methionine to SAMe). A short SAMe trial may also be warranted (SAMe is upstream from homocysteine).

[Kimer Med]

For my MTHFR mutations I followed the protocol from this website which for me means methylb12, regular Vitamin B6 and folic Acid are not good for me and I need adenosylcobalamin, hydroxycobalamin, P-5-P and (6s)-5-Methyltetrahydrofolate. But I’ve used all forms of each and never really noticed any positives or negatives.

https://methyl-life....st-form-of-b12/

 

Deciding on supplements or treatments based on SNPs alone is a risky thing. SNPs can help guide choices and understanding, but only when backed by specific symptoms or lab results.

 

The reason for this is that there is a difference between having a particular risk allele and the expression of that risk allele. Not all risk alleles are fully expressed!

 

Having said that, *everyone* should avoid Folic Acid. Bad stuff that's not found in nature. Sadly, it's a surprisingly common additive to processed foods these days, and it badly mucks with folate metabolism.

[John250]

Deciding on supplements or treatments based on SNPs alone is a risky thing. SNPs can help guide choices and understanding, but only when backed by specific symptoms or lab results.

The reason for this is that there is a difference between having a particular risk allele and the expression of that risk allele. Not all risk alleles are fully expressed!

Having said that, *everyone* should avoid Folic Acid. Bad stuff that's not found in nature. Sadly, it's a surprisingly common additive to processed foods these days, and it badly mucks with folate metabolism.

I agree I don’t think you can just go off mutations. For example it was recommended that I use AdenoB12 and you said it’s a deal for people with high Methylmalonic Acid (MMA) but my bloodwork showed

Methylmalonic Acid (MMA) 3.6 range 1.6-29.7
MMA normalized 1.6 range 0.4-2.5