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David Sinclair news?

nad sinclair

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#1 ortcloud

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Posted 01 September 2018 - 07:54 PM


What is the news about reprogramming cells?

 

I can't read the original news story from the Herald sun so I cant tell if this is new news or just rehashed stuff we know.

 

I can only read the daily mail reporting on the article.

http://www.dailymail...coffee-day.html

 

 

Can anyone read the original article? It is blocked behind a paywall

https://www.heraldsu...cf8e31b5560c7ae

 

It does not seem to be news about NAD, they mention that also, but that it is separate from this news.



#2 Phoebus

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Posted 01 September 2018 - 09:28 PM

 

 

'We do not recommend people go out and take NAD precursors as they have not yet formally tested for safety,' he said

 

 

its the usual NR/NMN hype, nothing new here as far as I can tell 



#3 ortcloud

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Posted 01 September 2018 - 11:31 PM

Its confusing, but the article talks about 2 different things.

 

A breakthrough in reprogramming cells and also NAD.

 

"Harvard Professor David Sinclair and researchers from the University of New South Wales developed the new process, which involves reprogramming cells."

 

"The same researchers also found they could increase the lifespan of mice by ten per cent by giving them a vitamin B derivative pill."

 

This would be 2 different things, right?



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#4 Phoebus

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Posted 02 September 2018 - 03:25 PM

Its confusing, but the article talks about 2 different things.

 

A breakthrough in reprogramming cells and also NAD.

 

"Harvard Professor David Sinclair and researchers from the University of New South Wales developed the new process, which involves reprogramming cells."

 

"The same researchers also found they could increase the lifespan of mice by ten per cent by giving them a vitamin B derivative pill."

 

This would be 2 different things, right?

 

 

pretty sure its this study 

 

https://www.scienced...71107113145.htm

 

more info here 

 

http://www.resveratr...1645/#more-1645



#5 izan82

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Posted 03 September 2018 - 12:40 AM

The article implies that Dr. Sinclair is directly supplementing himself with NAD


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#6 bluemoon

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Posted 03 September 2018 - 01:36 AM

The article implies that Dr. Sinclair is directly supplementing himself with NAD

But he has said he takes 750 mg of NMN each day.


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#7 ortcloud

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Posted 07 September 2018 - 04:44 PM

They are talking about something different, some type of cell reprogramming (not NAD or resveratrol/pterostilbene)

 

"In a world first, a team of researchers led by University of NSW and Harvard Professor David Sinclair has developed a cell reprogramming process that could regenerate the human body.

 

He predicts the development could eventually cure paralysis and allow people to regrow damaged kidneys, livers and other organs and it will be trialed in humans in 2020.

 

In a separate development, the same team has also developed a vitamin B derivative tablet that appears to reduce baldness and reverse infertility."

 

any ideas what this is?



#8 able

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Posted 07 September 2018 - 06:21 PM

They are talking about something different, some type of cell reprogramming (not NAD or resveratrol/pterostilbene)

 

"In a world first, a team of researchers led by University of NSW and Harvard Professor David Sinclair has developed a cell reprogramming process that could regenerate the human body.

 

He predicts the development could eventually cure paralysis and allow people to regrow damaged kidneys, livers and other organs and it will be trialed in humans in 2020.

 

In a separate development, the same team has also developed a vitamin B derivative tablet that appears to reduce baldness and reverse infertility."

 

any ideas what this is?

 

Pretty sure the  "separate development" is referring to what they now call Mib 626 - the combination of NMN and H2so4 they used in the March  study on mice endurance.  I haven't seen if they also used that in the just completed (not published) phase 1 human trials.

 

The gene reprogramming does seem to be a separate thing entirely.

 

They are pumping out a lot of pr lately.  Hope there is more big news coming.



#9 ortcloud

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Posted 07 September 2018 - 09:11 PM

Yeah, when they talk about curing paralysis and allowing people to regrow damaged kidneys and other organs...

 

that isnt NMN or NAD, that is something entirely different.

 

The discovery sounds kind of stem cell'ish but bigger.

 

If they can regrow organs that would be a big breakthrough.

 

So are they keeping this tight-lipped and no one knows what this is?



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#10 TMNMK

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Posted 10 September 2018 - 06:36 PM

My guess would be eliciting over-expression of the NRK's somehow. Crispr-related perhaps, just a guess.



#11 able

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Posted 10 September 2018 - 07:51 PM

Sinclair keeps pumping out interviews.  Here’s a really long one with some bits I found interesting:

 
"A few years later, the company he’d founded, Sirtris Pharmaceuticals, was bought for US$720 million by GlaxoSmithKline (his less than 1 per cent ownership stake still netted him a tidy sum)."
 
 - ​So he got less than $7 million before tax from that.
 
 
"Sinclair is aiming to get his own NAD+-boosting tablets on the market within three years. Unlike the other companies, he’s taking his research through the US FDA’s arduous drug-approval process so that, if clinical trials are successful, it can be sold not as a supplement but as a pharmaceutical drug, and prescribed by doctors. Since the FDA won’t approve drugs for treating old age, one of his companies, MetroBiotech, will market the boosters to treat rare diseases, and another, JumpStart Fertility, will sell them to reverse female infertility. The NAD+ booster furthest along in this process is called MIB-626; second-phase human trials are underway."
 
- I'm not totally sure, but believe MIB-626 is the NMN H2so4 combo that they used in the mouse study published in march
 
 
 
 
 
 

Edited by able, 10 September 2018 - 07:54 PM.

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#12 LawrenceW

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Posted 10 September 2018 - 08:52 PM

But he has said he takes 750 mg of NMN each day.

 

 

Last year he was taking 500 mg once per day. Apparently sometime in the last year he bumped that up to 750 mg.



#13 Phoebus

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Posted 10 September 2018 - 11:27 PM

 

 
- I'm not totally sure, but believe MIB-626 is the NMN H2so4 combo that they used in the mouse study published in march

 

 

 

where did you hear its includes an H2S factor? The only thing on 'MIB-26' googlihg comes up with is calling it an "NAD+ booster" 

 

thats it, nothing more descriptive. Not even sure if its related to NR/NMN at all. 

 

also H2So4 is sufuric acid, pretty sure you meant to refer to H2S ie hydrogen sulfide 


Edited by Phoebus, 10 September 2018 - 11:31 PM.


#14 bluemoon

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Posted 11 September 2018 - 12:49 AM

Last year he was taking 500 mg once per day. Apparently sometime in the last year he bumped that up to 750 mg.

 

You might be right but that should be verified by him.



#15 able

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Posted 11 September 2018 - 12:51 AM

You might be right but that should be verified by him.

 

He has said at least twice lately  in interviews  that he is using 750 mg NMN now.


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#16 able

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Posted 11 September 2018 - 12:54 AM

where did you hear its includes an H2S factor? The only thing on 'MIB-26' googlihg comes up with is calling it an "NAD+ booster" 

 

thats it, nothing more descriptive. Not even sure if its related to NR/NMN at all. 

 

also H2So4 is sufuric acid, pretty sure you meant to refer to H2S ie hydrogen sulfide 

 

definitely is NMN.  He keeps tossing out little bits of new info in each interview he has been giving lately. 

 

I don't know if that is by accident, or marketing genius.

 

I follow him on twitter, and he tweets about all his interviews there.

 

Here's the quote from Dailytelegraph article

 

 

In 2017 the team published research in the journal Science showing how a vitamin B derivative Nicotinamide Mononucleotide (NMN) reversed the decline in blood flow to tissues and organs associated with age and improved the exercise endurance of old mice by 60 per cent.

 
If it works in humans it would be the equivalent of giving a 70-year-old human the traits of a 20 year old.
 
The team have now developed an improved version of the NMN treatment which Sinclair calls “super NMN” that could be on the market in five years.
 
Mice given this new molecule — Mib 626 — ran on average twice as long as the control mice (those on NMN ran only 1.5 times as long)
 
Some mice on Mib 626 ran three times as far as the control mice and one broke the treadmill because he kept running for 3.5 kilometres in an incident known as “the great treadmill incident”.

Edited by able, 11 September 2018 - 01:18 AM.

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#17 Phoebus

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Posted 11 September 2018 - 02:10 AM

 

 
The team have now developed an improved version of the NMN treatment which Sinclair calls “super NMN” that could be on the market in five years.
 

 

ah!

 

so in other words its that key word...novel!!

 

that means its patentable and profitable and prescriptable. 

 

will it actually be better than NMN (which of course is not patentable)? who knows 

 

the big money investors couldn't give a sht about NMN even if it literally cured every disease known to man becase its not patentable. 


Edited by Phoebus, 11 September 2018 - 02:11 AM.

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#18 able

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Posted 11 September 2018 - 03:18 AM

ah!

 

so in other words its that key word...novel!!

 

that means its patentable and profitable and prescriptable. 

 

will it actually be better than NMN (which of course is not patentable)? who knows 

 

the big money investors couldn't give a sht about NMN even if it literally cured every disease known to man becase its not patentable. 

 

Yes, that is the point.  He is planning a drug that can be prescribed and paid for by insurance.  

 

The results in the march study did show better results with the addition of  H2s vs plain NMN.

 

Good enough for patents and getting the big investments.


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#19 ortcloud

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Posted 11 September 2018 - 04:53 PM

My best guess is that this news is about epigenome reprogramming using Yamanaka factors.

 

https://www.cell.com...8674(16)31664-6

  • Partial reprogramming erases cellular markers of aging in mouse and human cells
  • Induction of OSKM in progeria mice ameliorates signs of aging and extends lifespan
  • In vivo reprogramming improves regeneration in 12-month-old wild-type mice
Summary
Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging process through reprogramming has not been directly demonstrated in vivo. Here, we report that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging. Similarly, expression of OSKM in vivo improves recovery from metabolic disease and muscle injury in older wild-type mice. The amelioration of age-associated phenotypes by epigenetic remodeling during cellular reprogramming highlights the role of epigenetic dysregulation as a driver of mammalian aging. Establishing in vivo platforms to modulate age-associated epigenetic marks may provide further insights into the biology of aging.

 






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