1082 replies to this topic

[DJSwarm]

I read somewhere on this forum, I can't remember where, that if you do the Mayo Protocol you shouldn't do it monthly... or rather you should take a month off between doing it. Is that true, and if so why?

 

The Mayo protocol I'm familiar with uses 2 gm F x 2 days 3 weeks running and then a break. This was for an 80+ cohort so it should be safe for most. The only problem Is I've seen other reports that low dose F suppresses senolytic effects as an anti-inflammatory but it doesn't actually kill senescent cells until 4 grams. 6 grams is where the docs I've read start to suggest it could become problematic but its listed as GRAS without a posted upper limit on dose listed. So I go liposomal F (4 gm) + bioperine + bromelain so there is a remote chance to absorb. If I feel frisky I add Danasitinib as increases its effects like it does with liposomal quercetin (2 gm) so I usually stack them. Danasitinib (note: cancer drug could be risky) adds body load so keep the dose low, 60 mg or less.

 

Note elimination half life of F (4 hours), D (5) and Q (11), Avoid any pro-inflammatory during dosing (booze/nicotine/sugar). Fasting should increase effects. I like to pre-dose a while before with fiber to keep it all from just running through.

 

Remember you are blocking a key protein pathways. Don't do it constantly. 

 

For novelty purposes. Not medical advise.

[DJSwarm]

If you take 400 or 800 mg Fisetin per day for five days/month, how much would that interfere with the effect of blood thinners? (it's for my father) I know, he should talk to his doctor, but his doctor probably will have little knowledge about senolytics... Maybe he could start with smaller doses, see what the blood tests show and then gradually increasing.

 

Quick AI search:

Potential Interactions

• Increased Bleeding Risk: Fisetin has potential anti-platelet effects, which could intensify the action of blood thinners like warfarin (Coumadin) or apixaban (Eliquis), thereby raising the risk of bleeding.
• Metabolic Interference: Both fisetin and some blood thinners (e.g., warfarin) are processed by the same liver enzymes (such as CYP3A4). Fisetin could slow down the breakdown of the medication, causing it to stay in the body longer and become more potent, which increases side effect risks.
• Protein Binding: Studies suggest that fisetin might bind to human serum albumin (HSA) - the same protein binding sites as some drugs like warfarin. This could potentially displace the blood thinner, making more of the active drug available in the bloodstream and increasing its effect.
• Animal Study Data: Research in rats has shown that fisetin treatment significantly prolonged blood clotting time and other coagulation measures in a dose-dependent manner. 

[DJSwarm]

This guy puts out an attempt at a rebuttal to the study - believes the dosing level was too small:

 

https://youtu.be/IDOi0ODewjE?t=1985

 

Took a look.... 600 ppm (.6 mg/ml) for a 60 kg human, would be a HED of approximately (0.0486 mg/kg)(60kg)= ~2.9mg which is way too low for any effect.