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Ezogabine, a recently discontinued epilepsy drug, robustly decreases anhedonia

anhedonia depression mental illness

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#1 justabody

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Posted 29 November 2018 - 06:36 AM


https://www.eurekale...h-ads102918.php

 

 

NEW YORK, NY (November 1, 2018) Researchers from the Icahn School of Medicine at Mount Sinai found that patients with Major Depressive Disorder (MDD) exhibited a significant reduction of depressive symptoms after being treated with ezogabine, an FDA approved drug used to treat seizures.

 

After treatment, patients showed a 45 percent reduction in depression, a significant reduction in anhedonia, the inability to feel pleasure; and a significant increase in resilience.

 

 

The cruel irony is that it was discontinued and only available if you enter a randomized double-blind placebo trial. Potassium channel openers seem very promising to treat anhedonia, but I don't know of any drugs that share a similar mechanism of action with a low side-effect profile.

 


Edited by justabody, 29 November 2018 - 06:36 AM.


#2 jack black

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Posted 30 November 2018 - 05:53 PM

 

In 2013 FDA warned the public that, Potiga (ezogabine) can cause blue skin discoloration and eye abnormalities characterized by pigment changes in the retina. FDA does not currently know if these changes are reversible.

 

could this be related to the cancellation?

 

also:

 

 

Retigabine acts as a neuronal KCNQ/Kv7 potassium channel opener, a mechanism of action markedly different from that of any current anticonvulsants.[5][6][7] This mechanism of action is similar to that of the chemically-similar flupirtine,[15]

 

https://en.wikipedia...wiki/Retigabine


Edited by jack black, 30 November 2018 - 05:54 PM.


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