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[chziime]

Hi!

I hope I am posting in the right forum. I am currently weaning off of psychiatric medications, and I could not find a proper response in SurvivingAntidepressants.org.

I am currently weaning off of Remeron, followed by Zoloft. After that, all that remains is Depakote and Baclofen. After Remeron/Zoloft is out of my system, I also plan to slowly reintroduce supplements, specifically trying things like CBD and Black Seed Oil for my anxiety. I know not to mess with supplements during the withdrawal process due to my own sensitivity - all I currently take is Magnesium Glycinate and Ginger. I also know to avoid certain supplements and herbs because they inhibit liver enzymes that metabolize these medications, and thus don't maintain steady blood levels of the medications.

My question is... When I only have Depakote and Baclofen remaining to wean off of, could I begin to take certain supplements, now that the "heavy-hitter" anti-depressants (that are metabolized by the liver) are gone?

According to Wikipedia, Depakote is metabolized "Hepatic—glucuronide conjugation 30–50%, mitochondrial β-oxidation over 40%." So still in the liver, but not by the CYP450 system...? On the other hand, I've found these pages that do suggest Depakote is metabolized by CYP450:
https://www.ncbi.nlm...pubmed/17516991
https://www.pharmgkb...way/PA165964265

And according to Wikipedia, Baclofen is metabolized "85% excreted in urine/faeces unchanged. 15% metabolised by deamination," which seems mostly independent from the liver.

I am quite eager to safely experiment with non-habit forming supplements like Black Seed Oil, etc, and would like to try them as soon as I safely could. Thanks for any advice!!