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Nanotechnology hypersensible device for sensing early stage's cancer released proteins in a simple blood test

nanotechnology cancer proteins

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#1 Engadin

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Posted 10 January 2019 - 04:55 PM


"Early cancer detection will be achieved once that we can identify the protein biomarkers shed by the tumor to the bloodstream since its inception. Proteomic technologies, mainly mass spectrometry and multiplexed immunoassays, have rapidly developed during recent years with improved limits of detection and multiplexing capability. They can reliably explore the plasma proteome up to the ng/mL level, and in some cases to the pg/mL level. Still, thousands of unidentified proteins are expected to be discovered in the human plasma with major refinement of these proteomic technologies. However, access to the deepest region of the proteome will require of new ultrasensitive technologies capable of quantitating proteins in the plasma at concentrations several orders of magnitude lower than 1 pg/mL. This region of the plasma proteome is likely to contain specific protein biomarkers for early cancer detection. Here we propose the development of biological detectors based on nanomechanical systems for their incorporation into the technological arsenal of human proteomics. In particular, we point out to two recent developments, nanomechanical sandwich immunoassays and nanomechanical spectrometry. The first technique enables reproducible immunodetection of proteins at concentrations well below the pg/mL level, with a limit of detection on the verge of 10 ag/mL. This technology can potentially detect low abundance tumor-associated proteins at the very early stages of the tumor. Its level of development enables its rapid integration into the protein biomarker discovery pipeline. The second technique enables the identification of individual proteins by two physical coordinates, the mass and stiffness of the intact protein. Although still far from implementation in proteomics, it can easily benefit from the already MS advanced technologies for protein separation, nanoelectrospray ionization and efficient transport of protein ions in vacuum to the detector. We believe that in the near future nanomechanical protein detectors will play a fundamental role for deciphering the deepest region of the human plasma proteome. Let us cross the fingers for witnessing the discovery of specific cancer biomarkers that can save millions of lives every year by using a simple blood test."

 

https://www.sciencedirect.com/science/article/pii/S1044579X17300597

 

In the debate "NAD+ feeds already existing tumors while it fights the appearance of new ones", this sort of tests are THE way to enter a NAD+ therapy full throttle without any doubt or better stay away from it and look for other alternatives.


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