http://www.greenteat...th-blood-cancer
"Green Tea extract shows positive signs for people with blood cancer"
Looks like (according to the article) it improved white blood cell counts, kept lymph node swelling down, etc.
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Posted 30 April 2006 - 02:24 PM
Posted 30 April 2006 - 06:00 PM
Clinical effects of oral green tea extracts in four patients with low grade B-cell malignancies.
Shanafelt TD, Lee YK, Call TG, Nowakowski GS, Dingli D, Zent CS, Kay NE.
Mayo Clinic College of Medicine, Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Green tea or its constituents have long been touted as a health promoting substance including claims it may have cancer prevention properties. We previously reported the in vitro ability of one tea polyphenol, epigallocatechin gallate (EGCG), to induce apoptotic cell death in the leukemic B-cells from a majority of patients with chronic lymphocytic leukemia (CLL). After the publication of our findings many patients with CLL and other low grade lymphomas began using over-the-counter products containing tea polyphenols despite the absence of evidence to suggest clinical benefit, definition of possible toxicities, or information on optimal dose and schedule. We have become aware of four patients with low grade B-cell malignancies seen in our clinical practice at Mayo Clinic who began, on their own initiative, oral ingestion of EGCG containing products and subsequently appeared to have an objective clinical response. Three of these four patients met criteria for partial response (PR) by standard response criteria. Although spontaneous remission/regression is occasionally observed in individuals with low grade B-cell malignancies, such events are rare. Several patients presented here had documented steady clinical, laboratory, and/or radiographic evidence of progression immediately prior to initiation of over-the-counter green tea products and then developed objective responses shortly after self-initiating this therapy. Such anecdotes highlight the need for clinical trials of tea polyphenols to define the optimal dosing, schedule, toxicities, and clinical efficacy before widespread use can be recommended. An NCI sponsored phase I/II trial of de-caffeinated green tea extracts for patients with asymptomatic, early stage CLL opened at Mayo Clinic in August 2005.
PMID: 16325256 [PubMed - in process]
Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin.
Kundu T, Dey S, Roy M, Siddiqi M, Bhattacharya RK.
Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata 700 026, India.
Treatment of human leukemic cell lines HL-60 and K-562 with extracts of green and black tea and their polyphenols epigallocatechin gallate and theaflavins, respectively, showed a dose dependent inhibition of growth as a result of cytotoxicity and suppression of cell proliferation. Based on the IC50 values obtained from cytotoxicity data it was clearly evident that black tea was as efficient as green tea. Analysis of polyphenol contents of tea extracts revealed that not only epigallocatechin gallate, which is a predominant polyphenol of green tea, but also theaflavin that is abundantly present in black tea affords significant chemotherapeutic action by imparting cytotoxicity to human leukemic cells. Electrophoretic analysis of fragmented DNA from treated cells displayed characteristic ladder pattern. Flow cytometric analysis revealed the dose dependent increase in sub-G1 peak. These criteria confirmed that cytotoxic activity of green and black tea was due to induction of apoptosis. Such induction was found to be mediated through activation of caspases 3 and 8, particularly caspase 3 and by altering apoptosis related genes as evident by down-regulation of Bcl-2 and up-regulation of Bax proteins.
Posted 01 May 2006 - 05:27 AM
Posted 01 May 2006 - 06:38 AM
Any other supplements you'd immediately start taking?
Posted 01 May 2006 - 01:35 PM
The use of dietary supplements in a community hospital comprehensive cancer center: implications for conventional cancer care.
Gupta D, Lis CG, Birdsall TC, Grutsch JF.
Cancer Treatment Centers of America (CTCA) at Midwestern Regional Medical Center, Zion, IL, USA. digant.gupta@mrmc-ctca.com
GOALS OF WORK: There is little data on the prevalence of use of dietary supplements in cancer, especially in light of the growing evidence that some dietary supplements can have adverse interactions with conventional cancer treatment. The purpose of this study was to investigate the use of dietary supplements among adult cancer patients in a community hospital comprehensive cancer center. PATIENTS AND METHODS: A survey of 227 new adult cancer patients presenting for treatment for the first time at Cancer Treatment Centers of America at Midwestern Regional Medical Center, between November 2001 and October 2003. Patients completed the McCune Questionnaire, a validated instrument that captures information on the use of 56 dietary supplements in cancer, at admission to the hospital. RESULTS: Of the 227 patients, 73% used some form of dietary supplements during the 30 day period before the survey was conducted. Dietary supplement use was significantly higher (p = 0.04) in patients with colorectal (80%) and breast (75%) cancer as compared to patients with lung cancer (53%). Patients with stage II (86%) and III (76%) disease at diagnosis were more likely (p = 0.02) to use dietary supplements as compared to those with stage I (71%) disease at diagnosis, while those with stage IV (61%) disease at diagnosis were least likely to use them. Of the 80 patients who had received chemotherapy within the last 30 days, 71% had also used dietary supplements in that timeframe and 25% had consumed one or more herbal therapies that are suspected to have adverse interactions with chemotherapy. Of the 57 patients combining chemotherapy with dietary supplements, 52.6% did not consult a healthcare professional. CONCLUSIONS: In our study, twenty-five percent of patients receiving chemotherapy were concurrently using dietary supplements suspected to have adverse interactions with chemotherapy, usually relying on information sources other than healthcare professionals. Given the prevalence rates of these agents, healthcare providers should systematically inquire about them, and consider the potential for drug-dietary supplement interactions in treatment planning.
PMID: 15856334 [PubMed - indexed for MEDLINE]
Posted 04 May 2006 - 04:37 AM
Most importantly, I would advise my oncologist about the supplements that I was taking and about the supplements I was thinking of taking. If he questioned what I was taking I would ask for an explanation. In the case of my friend who was diagnosed recently, I went with him to the hospital and presented the oncologist with research papers to back up my recommendations.
Posted 04 May 2006 - 05:29 AM
Posted 04 May 2006 - 07:46 PM
Posted 04 May 2006 - 09:58 PM
Posted 08 May 2006 - 07:04 PM
Sorry to go off topic: but what's UP stellar, dude? You are the best. You did a good job kicking my ass when I was being a loon last summer. You were right -- too much dopamine sent me off the edge. Peace, Adam.
Posted 09 May 2006 - 05:44 AM
It's all water under the bridge at this point, Adam. [thumb]
Posted 09 May 2006 - 05:33 PM
Posted 09 May 2006 - 06:47 PM
Posted 10 May 2006 - 12:48 AM
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