13 replies to this topic

[stefan_001]

Interesting one to test:

https://patents.goog...0190008883A1/en

 

these swiss folks have a strong academic track record

Edited by stefan_001, 22 January 2019 - 07:46 AM.

[Phoebus]

intersting, combining NR with a mitophagy inducer 

 

 

 

In laboratory studies, urolithin A was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging.^[15] This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).^[15]

 

 

by the way ellagic acid breaks down into urolithin A, so perhaps that might be a great addition to an NR protocol 

 

 

 

Urolithins, such as urolithin A, are microflora human metabolites of dietary ellagic acid derivatives that are under study as anti-cancer agents.^[21] Claims that ellagic acid can treat or prevent cancer in humans have not been proven.^[22]

 

Edited by Phoebus, 23 January 2019 - 05:28 AM.

[Harkijn]

Thanks for posting this Stefan, interesting find! For readers that have missed the Urolithin threads and want to read up on it I post a link to one  here.

Most days I drink a glass of 100% pomegranate juice . I will now start to take it simultaneously with my NR.

https://www.longecit...y-fight-ageing/

[Fafner55]

There appears to be synergies with NR an Urolithin A in enhancing autophagy in general and mitophagy in particular through activating the AMPK pathway (the same pathway as calorie restriction).

 

It has been shown that SIRT1 activates AMPK, and as we know NR is an essential cofactor for sirtuins.

"SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function" (2013) https://www.ncbi.nlm...les/PMC3545644/

 

There is also evidence that urolithins activate AMPK.

"Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms" (2013) https://www.ncbi.nlm...les/PMC5015040/

 

Autophagy induction with liposomal trehalose works by activating the same AMPK pathway, as discussed in this thread.

 

 

[Fafner55]

Here's more support that urolithin A activates AMPK.

 

"Urolithin A, C and D, but not iso-Urolithin A and Urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes" (2016) https://pdfs.semanti...ef0af22c256.pdf

Edited by Fafner55, 23 January 2019 - 12:57 PM.

[Daniel Cooper]

I'd buy that today if it were available.  I'm been looking for an affordable source of Urolithin A for some time now.  Barring that, a source for gordonibacter urolithinfaciens.

 

 

 

[Fredrik]

Nestlé Health Sciences has struck license agreements with both Chromadex (NR) and Amazentis SA (that is producing the oral Urolithin A and is behind the recent publications on mitophagy in humans).

 

Nestlé will probably put both molecules in their supplemental drinks (or NR in a snack bar/powder form if they cannot solve the instability problem with NR in solution) to combat sarcopenia in the elderly as well as cognitive decline and other conditions. Interesting times.

 

Here is Amazentis SA pop-science site on Urolithin A with pressreleases and as a bonus, a video of scientist John Auwerx handling a pomegranate:

 

https://abouturolithina.com/

Edited by Fredrik, 19 June 2019 - 11:27 AM.

[Daniel Cooper]

Nestlé Health Sciences has struck license agreements with both Chromadex (NR) and Amazentis SA (that is producing the oral Urolithin A and is behind the recent publications on mitophagy in humans).

 

Nestlé will probably put both molecules in their supplemental drinks (or NR in a snack bar/powder form if they cannot solve the instability problem with NR in solution) to combat sarcopenia in the elderly as well as cognitive decline and other conditions. Interesting times.

 

Here is Amazentis SA pop-science site on Urolithin A with pressreleases and as a bonus, a video of scientist John Auwerx handling a pomegranate:

 

https://abouturolithina.com/

 

 

The question is, will it be a prescribed drug, or a supplement?  

 

If drug, we aren't going to see this for awhile.

[Fredrik]

The question is, will it be a prescribed drug, or a supplement?  

 

If drug, we aren't going to see this for awhile.

 

It will be a dietary supplement according to the pressrelease. The medicinal nutrition product may be prescribed (less costly) by a dietitian like myself, or bought without a prescription. 

 

The optimal dose of Urolithin A was 1000 mg in their study. Expecting a combined NR/UA capsule and perhaps a NR/UA powder with creatine if they follow through with the ideas in the patent. We´ll see.

 

"Nestlé Health Science will take an equity stake in Amazentis and receive global rights to use Amazentis’ patented Urolithin A technology for dietary supplements, select foods and beverages, and medical nutrition products. "

 

http://pdf.amazentis...pril_2_2019.pdf

Edited by Fredrik, 19 June 2019 - 02:53 PM.

[Daniel Cooper]

Excellent. I'd love to get access to that right now.

 

Any rumors on when it might become available?

 

 

 

[Phoebus]

Excellent. I'd love to get access to that right now.

 

Any rumors on when it might become available?

 

 

 go to the link and sign up for an email notificiation, thats what I did 

 

 

 

https://amazentis.e-unit.ch/

It will be a dietary supplement according to the pressrelease. The medicinal nutrition product may be prescribed (less costly) by a dietitian like myself, or bought without a prescription. 

 

The optimal dose of Urolithin A was 1000 mg in their study. Expecting a combined NR/UA capsule and perhaps a NR/UA powder with creatine if they follow through with the ideas in the patent. We´ll see.

 

"Nestlé Health Science will take an equity stake in Amazentis and receive global rights to use Amazentis’ patented Urolithin A technology for dietary supplements, select foods and beverages, and medical nutrition products. "

 

http://pdf.amazentis...pril_2_2019.pdf

 

 

why creatine though? What does that add to the mix? 

[Fredrik]

why creatine though? What does that add to the mix?

As an energy back up? To provide a quick supply of ATP to energy hungry cells (neurons, muscle cells, heart) when all ATP has been used up and no new ATP has been created.

[MikeDC]

The results are impressive. But will it improve health or cause issues? Too much of anything could be bad.

[Fredrik]

@MikeDC Just follow the dosing used in human trials with urolithin A = up to 1000 mg. Same with NR.