7 replies to this topic

[scottl]

Neuropsychobiology. 1990-91;24(3):159-64. Related Articles, Links

Psychopharmacological effects of pyritinol in normal volunteers.

Hindmarch I, Coleston DM, Kerr JS.

HPRU, Robens Institute, University of Surrey, Guildford, UK.

Twelve healthy male volunteers received pyritinol 600 or 1,200 mg or placebo for 3 days according to a randomised, double-blind crossover design. On the 1st and 3rd days of each of the three treatment periods subjects completed a battery of psychological tests including Critical Flicker Fusion (CFFT), Choice Reaction Time (CRT), tests of memory and subjective drug effects at 1, 2, 4 and 6 h after dosing. Significant improvements in CFFT and CRT were found after pyritinol. There were no significant differences on the other tests, however, the observed enhancement in performance could be attributed to the effect of the drug.

Publication Types:
* Clinical Trial
* Randomized Controlled Trial
PMID: 2135070 [PubMed - indexed for MEDLINE]

Ful PDF is here:

http://www.sciencedi...74113299b346958

[zoolander]

I used to use pyritinol. I never used pyritinol in isolation so cannot say conclusively that there was an enhancement in performance after pyritnol consumption. I have taken pyritinol dosages as high as 1200 mg per day. Whilst I was taking pyritinol, I did not experiance any adverse side effects. The only nootropic that I have experianced mild adverse side effects with is galantamine.

I do not take pyritinol anymore. I have been scared off by the following case studies

Severe cholestatic hepatitis induced by pyritinol and Acute pancreatitis due to pyritinol: an immune-mediated phenomenon..

I know they are only case studies but the people seemed to be in good health and discontinuation of pyritinol resulted in a return to normal clinical values.

[scottl]

Zoolander,

1. I ain't promoting this stuff jsut trying to correct bad press.

2. I will adress prometheus comments in time re: ATP levels.

3. If you look for case studies and avoid things because of it, you would never take anything. Asprin which is the standard for safety re: pyritinol in a thread at M & M I will not take because I value my kidneys and am not willing to take that small risk.

4. People with rheum arthritis need to be really careful with this stuff and perhaps avoid it unless necessary.

5. Nothing is without risk in life i.e. there were a number of marathonners who died from too much water. One needs to take responsibility for one's choices and see if the risk of anything is worth the potential benefit.

[neuroenhanced]

I'm not aware of any major benefit of Pyritinol and the possible side effects would seem to exclude it from the list of nootropics. Is there any science backed positive effects it has?

[Phreak]

okay, so there has been a few case studies and theories that show pyritinol to be toxic or whatever. However, these seem to happen when taking pyritinol at high doses (600mg+) every day.

i still want to try pyritinol however

so my question is, are these risks still a huge factor when taking doses of 400mg every OTHER day. (ie. 1600mg spaced out over one week). I was thinking of doing this because i AM aware of the potential dangers, but I also am aware of the cognitive benefits and I don't want to just throw away my $30's worth. so yeah, am I looking at any serious (potential) health risks when taking so little sporadicially?
On a similar note, am I looking at receiving the beneficial cognitive effects as well if I take such a dose?

thanks

[quicksilver]

Zoolander,

1. I ain't promoting this stuff jsut trying to correct bad press.

2. I will adress prometheus comments in time re: ATP levels.

3. If you look for case studies and avoid things because of it, you would never take anything.  Asprin which is the standard for safety re: pyritinol in a thread at M & M I will not take because I value my kidneys and am not willing to take that small risk.

4. People with rheum arthritis need to be really careful with this stuff and perhaps avoid it unless necessary.

5. Nothing is without risk in life i.e. there were a number of marathonners who died from too much water.  One needs to take responsibility for one's choices and see if the risk of anything is worth the potential benefit.

Scottl i thought it's approved use was for rheumatoid arthritis?

[russianBEAR]

Pyrinol was actually pretty awesome, a much "cleaner" feeling than Piracetam.

I don't really recall ever taking more than 600mg in a 24-hour period. No instruction manual I've found recommends a daily dose of more than 400mg, in some cases going as low as 150 or even 50 for young children.

Please note that it can raise "liver" transaminase levels, and hepatitis is also directly mentioned in the list of possible side effects.

Forget about it if you have rheumatoid arhritis and other joint ailments, as there's a whole plethora of side effects just for that. 

The allergic reactions seem to have more to do with the substances of its group than actual allegry. I had nothing like that while I've been quite allergic to things in the past. 

These are all excerpts from the instruction manuals found in the Encephabol we purchase here. Also phramacies are A LOT more unwilling to give you this without a prescription than most other noots, although normally they're all listed as strictly presciption only.

Hope that helped, there are a lot more big words and diseases I've never ever heard of listed in the side effects column, I'd have to look them up if you care to know ALL about it.

[qemist]

Pyrinol was actually pretty awesome, a much "cleaner" feeling than Piracetam.

I don't really recall ever taking more than 600mg in a 24-hour period. No instruction manual I've found recommends a daily dose of more than 400mg, in some cases going as low as 150 or even 50 for young children.

Please note that it can raise "liver" transaminase levels, and hepatitis is also directly mentioned in the list of possible side effects.

Forget about it if you have rheumatoid arhritis and other joint ailments, as there's a whole plethora of side effects just for that. 

Hope that helped, there are a lot more big words and diseases I've never ever heard of listed in the side effects column, I'd have to look them up if you care to know ALL about it.

People keep saying that, yet Pyritinol has been trialled as a treatment for rheumatoid arthritis.

How is pyritinol different/better than pyridoxine?