Please show me evidence that 6 meals/day have a greater metabolic affect than 3 meals/day.
I am curious to see the studies with statistical numerical results.
Not because I don't believe it's true (and Shep, I hope you're not implying such), but because I'm curious just how pronounced the effect is. 6 meals/day versus 3 meals/day probably has a much smaller marginal effect than say 3/day versus 1/day.
The basic idea is that when fasting, your body undergoes shifts in metabolism that effect A) more efficient use of calories, at the mitochondrial level (and probably other levels as well), and B) reduced energy needs for non-basic metabolic functions. Lethargy is also effected, which reduces calorie consumption through reduced activity levels (i.e., this effect we have more conscious control over: exert enough will, and this latter effect is probably minimalized).
However, note that I said "fasting". These changes are well documented for fasting periods of 16-18 hours, so my statement of 3 meals/day versus 1 meal/day is easily substantiated.
But I am curious what the shorter term changes are (e.g. of 6/day versus 3/day), and whether they even significantly approach the changes seen with fasting. If not, then the primary benefit of 6/day is merely glucose/insulin control (which affects appetite and lethargy, i.e., the consciously-controlled portions of the weight-loss equation).
And don't underestimate the weight-loss benefits of glucose/insulin control, especially for those with overweight/obesity issues to begin with.
Bear in mind that the larger glucose/insulin spikes of 3 meals/day in sedentary individuals
will lead to a larger portion of calories being depostited in adipose (fat) tissue, followed by longer periods of lethargy. Calories can go into adipose tissue very rapidly, via insulin, but come back out very slowly until one reaches a fasting state. (Exercise in a fasting state accelerates free fatty acid release from adipose tissue.)
So for weight loss, there are multiple benefits to 6 meals/day (especially if you're not exercising), though the main benefits won't be from the metabolic standpoint (though there's probably some measurable effect there, and as I said, I'd be interested to see the numbers in a study), but from the standpoint of reduced storage into adipose tissue, decreased lethargy, and increased appetite control.
On the flipside, weight gain can also benefit from greater meal frequency, depending on the type of protein you eat. If you're eating slowly digested protein sources, such as meat/eggs, cheese, etc., then meal frequency isn't as important. If you're using fast protein sources, such as whey, then greater meal frequency will have a benefit, because blood amino acid levels need to be high to prevent catabolism and promote anabolism. Blood amino acid levels will spike very high, which is good for anabolism, but will drop rapidly (not sure on the numbers, but after 2-3 hours sounds about right) after consuming whey protein.
Finally, concerning rapid weight loss. There is plenty of epidemiological evidence that rapid weight loss can be bad, but bear in mind that rapid weight loss is usually associated with A) disease, B) malnutrition, C) muscle loss, and/or D) mineral loss.
If you're not losing weight due to disease (e.g. cancer), then A isn't a concern. Maintaining high micronutrient levels (via nutritionally dense foods and/or supplements) will help prevent B, high protein levels (with every meal) will help prevent C, and mineral supplements (including large doses of vitamin D and calcium [which you should take with the proper ratio of magnesium]) will help prevent D.
This of course doesn't guarantee that the rapid weight loss won't be unhealthy, but it minimizes the risk.