http://seattlepi.nws...mallpox18.shtmlWednesday, December 18, 2002
Smallpox vaccine risks outweigh benefits (excerpts)
By MARC SIEGEL
PROFESSORFor military personnel and health care and emergency workers, immediate vaccination is probably prudent. The old live-virus vaccine offers temporary immunity against smallpox.
In fact those who received this vaccine more than 30 years ago probably still have some protection.
But the old vaccine has a real downside. It can cause brain swelling, skin problems and infection, problems that are not insignificant when millions of people are being vaccinated.
Further, there are other smallpox vaccines in the works that appear to be safer. In two of these vaccines the viral particles used are not live.
One version is undergoing clinical trials at the National Institutes of Health. Another version has been used in Japan to immunize hundreds of thousands of people.
It would be foolish to vaccinate millions of people here in a panic, only to discover that a better, safer vaccine is on the verge of being approved.
If smallpox hits, the most important response will be to quarantine those who have been infected, since smallpox generally spreads from person to person via airborne droplets.
The second most important response will be to administer the live vaccine in areas where the disease has appeared, for immunization after infection reduces the mortality rate to less than 10 percent. No matter how smallpox arrives -- if it does arrive -- there will be plenty of time to react before a large population is affected.
Marc Siegel is associate professor of medicine at the New York University School of Medicine. Copyright 2002 The New York Times.
Edited by bobdrake12, 29 March 2003 - 11:45 PM.