7 replies to this topic

[Jesuisfort]

Hello, I'm looking for supplement highly effective in cancer prevention  and  that can destroy cancer at early stage 

 

I found these 2  popular supplements : Curcumin and Sulforaphane

 

The problem is  some people told me that curcumin and sulforaphane  may cause DNA damage at normal dosage ! that's why i'm really afraid to use them, what do you think ? 

 

Do you know any other supplement that can prevent cancer ?  I particulary want to prevent ORAL CANCER ( palate, tongue, lips...) 

 

 

[tunt01]

Think the dose makes the poison, but I'd be surprised if curcumin was toxic at even very high doses.

 

 

From my notes:

 

• We observed cellular senescence after using curcumin in 2.5–5 μM concentrations range, and the highest concentration described in the serum was 3.6 μM [1].
• From one of the studies on longvida the concentration max (Cmax)  88 nmol/L, 85 nmol/L, and 111 nmol/L at doses of 2, 3, and 4 grams respectively.

 

So actual patients had about 1/61th of the observed level that required toxicity at 2.5 μM.  I think it would require an unbelievable dose to trigger genotoxicity or alternatively your liver would have to be basically not functioning (I guess).  Maybe someone has better data on this issue, but this is my off the hand 10 minute analysis/input.

 

 

1. Grabowska, W., Kucharewicz, K., Wnuk, M., Lewinska, A., Suszek, M., & Przybylska, D. et al. (2015). Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner. AGE, 37(1). doi:10.1007/s11357-014-9744-y

 

 

 

 

 

Edited by tunt01, 05 March 2019 - 12:07 AM.

[joelcairo]

There have been many studies of curcumin in humans, often at quite high doses. Honestly I think it would be hard to find even an animal study where curcumin did any detectable harm, not counting high-dosage studies that set out to trigger toxic effects.

 

I would not necessarily recommend this product for children or even young adults who are still growing (maybe age 20 or so). Also it would be a common sense not to supplement this during pregnancy, as this molecule interacts with a lot of proteins and biological processes related to growth & angiogenesis signaling. IMO it's more for older adults who may be harboring some dysfunctional cells and likely have more inflammation going on than they need.

 

Not really certain about sulforaphane. It's not nearly as well studied so the unknowns are greater.

 

See also low dose aspirin, melatonin, omega-3 fatty acids.

[Dorian Grey]

IP6 (inositol hexaphpsphate) has some remarkable anti-cancer properties, and a remarkably benign safety profile.  

 

https://pdfs.semanti...fd9417633c1.pdf

 

Interestingly, iron chelation is supposed to be the protective action from IP6, & Curcumin is also an iron chelator.  

 

https://www.ncbi.nlm...pubmed/16545682

 

There is also cancer reduction to the "upper aerodigestive" organs reported in a study of iron reduction through phlebotomy (blood donation) for Peripheral Arterial Disease.  

 

https://pdfs.semanti...71cd143babd.pdf

 

"Upper aerodigestive" : "Total 7, control 6, iron reduction 1"

 

Most all cancers were greatly reduced in the iron reduction group. From Table 1 (bladder cancer was the joker in the deck & pancreatic not statistically significant)

 

(total, control & iron reduction groups respectively)

 

Lung 38 23 15

Colorectal 13 9 4

Prostate 12 8 4

Upper aerodigestive 7 6 1

Bladder 8 1 7

Pancreas 1 0 1

Other* 19 13 6

Total 98 60 38 *

 

The 19 cancers at other sites include melanoma (n=4); lymphoma, soft tissue sarcoma, adenocarcinoma of unknown primary, malignant carcinoid, and hepatocellular (n=2 each); and multiple myeloma, renal cell, metastatic pancreatic endocrine carcinoma, gastric, and cholangiocarcinoma (n=1 each).

 

A critique of this "Too Good to be True" incidental finding is discussed here: 

 

https://academic.oup...0/14/976/920610

 

Don't know if your concern about oral cancers are tobacco related, but tobacco has a high iron content, & there has been speculation that the iron particulate of tobacco smoke may be one of the primary carcinogens.  I expect the same would be true for snuff/snus & oral cancers.  An IP6 in water mouth rinse before bed might be an effective protocol for oral tobacco use if this is the case.

 

Stay Healty My Friend! 

Edited by Dorian Grey, 06 March 2019 - 04:49 AM.

[Jesuisfort]

thank you all guys for your  replies !  

so it seem curcumin  is a good supplement  for my purpose, I will do more research about it 

Also I will look into IP6 ! it seem to be very good 

[capob]

IP6 (inositol hexaphpsphate) has some remarkable anti-cancer properties, and a remarkably benign safety profile.  

 

https://pdfs.semanti...fd9417633c1.pdf

 

Interestingly, iron chelation is supposed to be the protective action from IP6, & Curcumin is also an iron chelator.  

 

https://www.ncbi.nlm...pubmed/16545682

 

There is also cancer reduction to the "upper aerodigestive" organs reported in a study of iron reduction through phlebotomy (blood donation) for Peripheral Arterial Disease.  

 

https://pdfs.semanti...71cd143babd.pdf

 

"Upper aerodigestive" : "Total 7, control 6, iron reduction 1"

 

Most all cancers were greatly reduced in the iron reduction group. From Table 1 (bladder cancer was the joker in the deck & pancreatic not statistically significant)

 

(total, control & iron reduction groups respectively)

 

Lung 38 23 15

Colorectal 13 9 4

Prostate 12 8 4

Upper aerodigestive 7 6 1

Bladder 8 1 7

Pancreas 1 0 1

Other* 19 13 6

Total 98 60 38 *

 

The 19 cancers at other sites include melanoma (n=4); lymphoma, soft tissue sarcoma, adenocarcinoma of unknown primary, malignant carcinoid, and hepatocellular (n=2 each); and multiple myeloma, renal cell, metastatic pancreatic endocrine carcinoma, gastric, and cholangiocarcinoma (n=1 each).

 

A critique of this "Too Good to be True" incidental finding is discussed here: 

 

https://academic.oup...0/14/976/920610

 

Don't know if your concern about oral cancers are tobacco related, but tobacco has a high iron content, & there has been speculation that the iron particulate of tobacco smoke may be one of the primary carcinogens.  I expect the same would be true for snuff/snus & oral cancers.  An IP6 in water mouth rinse before bed might be an effective protocol for oral tobacco use if this is the case.

 

Stay Healty My Friend! 

 

 

After all these years, you've finally got me to look into IP6 to some depth.

 

I didn't know it had an effect on glycolysis:

 

[Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis.](https://www.ncbi.nlm...pubmed/28404949)

- `IP6 exposures had modest to minimal effects on cell proliferation, we observed reduced cellular glycolysis, down-regulation of PI3K/Akt signaling and suppression of OS metastatic progression`

- _!_ Importantly, it is affecting the primary engine of cancer - glycolysis.

 

I still have questions about its effect on normal cells.  One study indicates it benefits stem cells

 

[Effect of dentine conditioning with phytic acid or etidronic acid on growth factor release, dental pulp stem cell migration and viability.](https://www.ncbi.nlm...pubmed/30585644)

- `Cell proliferation significantly increased with time after ... IP6 treatment`

- `... effective chelating agents on TGF-β release`

 

while another indicates it has a varied affect on osteoblasts (depending on types)

 

[Differential response of MC3T3-E1 and human mesenchymal stem cells to inositol hexakisphosphate.](https://www.ncbi.nlm...pubmed/23221481)

- `IP6 decreased gene expression of osteoblast markers and mineralization in MC3T3-E1 cells without negatively affecting cell viability and ALP activity, an increase in gene expression of ALP was observed in hUC-MSCs committed to the osteoblastic lineage`

- `This increasing effect of IP6 on ALP mRNA expression levels was reversed by the addition of a selective inhibitor of IP6 kinase, suggesting that the effect of IP6 might be due through its pyrophosphorylated derivatives.`

- `Rankl mRNA levels were decreased ... pointing to a paracrine effect on osteoclasts.`

 

I've compiled what I found here https://grithin.com/...aphosphate-ip6/

 

[Dorian Grey]

Great page on IP6 capob (and interesting site!).  For all you do, we salute you!  

Edited by Dorian Grey, 11 March 2019 - 10:50 PM.

[Engadin]

Several thousand millions inhabitants of India in the tenths of centuries they have been consuming turmeric, and therefore curcuma, may claim the contrary if you ask. Probably.