Probably.. But I think you need deep pockets if it slips illegally to the market.
In Europe it's in Pre-registration (Filed) but not approved yet but probably will.. In which way I don't know.. Guess like in the US as a controlled substance.
Btw, you might want to look into the research on the interaction between the serotonin system and ketamine - apparently the 5ht1b receptor may be involved - I'm not sure if it's an agonistic or antagonistic end result though...
Regardless, multiple antipsychotics with varying serotonin modulating effects exist - perhaps a combo of an antipsych which agonises 5ht1a, heavily ANTagonises 5ht2a, and some effect on 5ht1b, could ENHANCE the effects of Ketamine, while also keeping you more sane?
Worth looking into.
Ref:
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PET studies of the serotonin system in major depression and its treatment
https://openarchive....dle/10616/42184
Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus
https://www.ncbi.nlm...les/PMC5838842/
(might want to use a nicotinic agonist as well - since there appears to be interaction with the cholinergic system - which is also involved in the pathology of Schiz'.)
A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques
https://www.nature.c...icles/tp2013112
...ketamine administration significantly increased 5-HT1B receptor binding in the nucleus accumbens and ventral pallidum, whereas it significantly reduced SERT binding in these brain regions.
...a potent antagonist of the glutamate α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor, blocked the action of ketamine on the 5-HT1B receptor but not SERT binding. This indicates the involvement of AMPA receptor activation in ketamine-induced alterations of 5-HT1B receptor binding.
Ok - seems like Agonism is the name of the game - because up-regulation = natural agonism.
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies
https://www.scienced...163725819300403